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Targeting metabolism to improve CAR-T cells therapeutic efficacy

Shasha Liu Yuyu Zhao Yaoxin Gao Feng Li Yi Zhang

中华医学杂志（英文版）2024，Vol.137Issue(8)：909-920,12.

中华医学杂志（英文版）2024，Vol.137Issue(8)：909-920,12.DOI:10.1097/CM9.0000000000003046

Targeting metabolism to improve CAR-T cells therapeutic efficacy

Shasha Liu ¹Yuyu Zhao ²Yaoxin Gao ¹Feng Li ³Yi Zhang⁴

作者信息

1. Biotherapy Center and Cancer Center,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China
2. Biotherapy Center and Cancer Center,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China||School of Life Sciences,Zhengzhou University,Zhengzhou,Henan 450052,China
3. Biotherapy Center and Cancer Center,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China||Engineering Key Laboratory for Cell Therapy of Henan Province,Zhengzhou,Henan 450052,China
4. Biotherapy Center and Cancer Center,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China||School of Life Sciences,Zhengzhou University,Zhengzhou,Henan 450052,China||Engineering Key Laboratory for Cell Therapy of Henan Province,Zhengzhou,Henan 450052,China||School of Public Health,Zhengzhou University,Zhengzhou,Henan 450000,China
折叠

摘要

关键词

CAR-T cell therapy/Metabolism/Tumor microenvironment/Immunotherapy/Mitochondrial fitness

Key words

CAR-T cell therapy/Metabolism/Tumor microenvironment/Immunotherapy/Mitochondrial fitness

引用本文复制引用

Shasha Liu,Yuyu Zhao,Yaoxin Gao,Feng Li,Yi Zhang..Targeting metabolism to improve CAR-T cells therapeutic efficacy[J].中华医学杂志（英文版）,2024,137(8):909-920,12.

基金项目

This work was supported by grants from National Key Research and Development Program Intergovernmental Key Project for International Science and Technology Innovation Cooperation(No.2022YFE0141000),Natural Science Foundation of China(No.82203548),China Postdoctoral Science Foundation Project(No.2022M712894),Medical Science and Technology Project of Henan Province(No.LHGJ20220385),and Major science and technology project of Henan Province(No.221100310100). （No.2022YFE0141000）

中华医学杂志（英文版）

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