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Caloric restriction,Sirtuins,and cardiovascular diseasesOACSTPCDMEDLINE

Caloric restriction,Sirtuins,and cardiovascular diseases

英文摘要

Caloric restriction(CR)is a well-established dietary intervention known to extend healthy lifespan and exert positive effects on aging-related diseases,including cardiovascular conditions.Sirtuins,a family of nicotinamide adenine dinucleotide(NAD+)-depen-dent histone deacetylases,have emerged as key regulators of cellular metabolism,stress responses,and the aging process,serving as energy status sensors in response to CR.However,the mechanism through which CR regulates Sirtuin function to ameliorate cardiovascular disease remains unclear.This review not only provided an overview of recent research investigating the interplay between Sirtuins and CR,specifically focusing on their potential implications for cardiovascular health,but also provided a comprehensive summary of the benefits of CR for the cardiovascular system mediated directly via Sirtuins.CR has also been shown to have considerable impact on specific metabolic organs,leading to the production of small molecules that enter systemic circulation and subsequently regulate Sirtuin activity within the cardiovascular system.The direct and indirect effects of CR offer a potential mechanism for Sirtuin modulation and subsequent cardiovascular protection.Understanding the interplay between CR and Sirtuins will provide new insights for the development of interventions to prevent and treat cardiovascular diseases.

Ziyu Wei;Bo Yang;Huiyu Wang;Shuangjie Lv;Houzao Chen;Depei Liu

State Key Laboratory of Common Mechanism Research for Major Diseases,Department of Biochemistry and Molecular Biology,Institute of Basic Medical Sciences,Chinese Acade-my of Medical Sciences & Peking Union Medical College,Beijing 100005,China

Caloric restrictionSirtuinsCardiovascular diseasesHealthy lifestyleDietary

《中华医学杂志(英文版)》 2024 (008)

921-935 / 15

This work was supported by grants from the National Key Research and Development Project of China(Nos.2020YFC2008003,2021YFA0804900,and 2019YFA0801500),the National Natural Science Foundation of China(Nos.92149305,82225007,and 82030017),and the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(Nos.2021-I2M-1-016,2022-I2M-JB-006,and 2022-I2M-2-002).

10.1097/CM9.0000000000003056

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