Serum 25-hydroxyvitamin D,genetic susceptibility,and the risk of incident type 2 diabetes:A prospective cohort in East ChinaOACSTPCDMEDLINE
Serum 25-hydroxyvitamin D,genetic susceptibility,and the risk of incident type 2 diabetes:A prospective cohort in East China
Background:The serum vitamin D level varies widely by population,and studies have linked vitamin D levels with the risk of type 2 diabetes mellitus(T2DM).However,the relationship is inconsistent and the impact of vitamin D on T2DM among East Chinese adults is unclear.The study aimed to investigate the association between serum 25-hydroxyvitamin D(25[OH]D)levels and the risk of T2DM and evaluated whether the association is modified by genetic predisposition. Methods:In the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors(SPECT-China)cohort,1862 participants free of T2DM at baseline were included.A weighted genetic risk score was calculated with 28 variants associated with T2DM.Hierarchical logistic models were used to examine the association of serum 25(OH)D and genetic risk with T2DM. Results:After a 5-year follow-up,132 cases of T2DM were documented.We observed no significant association between quartiles of serum 25(OH)D and T2DM risk after multivariable adjustment(x2=0.571,Pfortrend=0.426).Compared to those in the lowest quartile of 25(OH)D,the odds ratios(ORs)(95％confidence interval[CI])for participants with increased quartiles were 1.29(0.74-2.25),1.35(0.77-2.36),and 1.27(0.72-2.24),respectively.We observed a positive association of glycated hemoglobin(HbA1c)with 25(OH)D at baseline(β=1.752,P=0.001)and after follow-up(β=1.385,P=0.003),and a negative association of In conversion homeostasis model assessment(HOMA)-β with 25(OH)D at baseline(β=-0.982,P=0.021).There was no significant interaction between 25(OH)D and diabetes genetic predisposition on the risk of T2DM(x2=2.710,Pforinteraction=0.100).The lowest OR(95％CI)of T2DM was among participants with low genetic risk and the highest quartile of 25(OH)D(0.17[0.05-0.62]). Conclusion:Serum 25(OH)D may be irrelevant to the risk of incident T2DM among East Chinese adults regardless of genetic predisposition.
Ying Sun;Haojie Zhang;Bin Wang;Yuying Wang;Chi Chen;Yi Chen;Yingli Lu;Ningjian Wang
Institute and Department of Endocrinology and Metabolism,Shanghai Ninth People's Hospital,Shanghai JiaoTong University School of Medicine,Shanghai 200011,ChinaDepartment of Endocrinology and Metabolism and Department of Guideline and Rapid Recommendation,Cochrane China Center,MAGIC China Center,Chinese Evidence-Based Medicine Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,ChinaDepartment of Endocrinology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
Vitamin DDiabetes mellitus,Type 2Genetic predisposition to diseaseProspective cohortGlycated hemoglobinSPECT-China
《中华医学杂志（英文版）》 2024 (008)
972-979 / 8
This study was supported by grants from the Clinical Research Plan of SHDC(No.SHDC2020CR4006),Shanghai Ninth People's Hospital(No.YBKB202218),Shanghai Municipal Human Resources and Social Security Bureau(No.2020074),and National Natural Science Foundation of China(No.82170870).
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