DOT1L介导Notch1信号通路对喉鳞状细胞癌上皮间质转化的机制OACSTPCD
The mechanism of DOT1L on epithelial mesenchymal transition in laryngeal squamous cell carcinoma via Notch1 signaling pathway
目的 探讨类端粒沉默干扰体 1(disruptor of telomeric silencing 1-like,DOT1L)介导Notch1信号通路对喉鳞状细胞癌(laryngeal squamous cell carcinoma,LSCC)上皮间质转化(epithelial mesenchymal transition,EMT)的作用机制.方法 选择30例病理确诊LSCC患者的肿瘤组织和癌旁组织,免疫组织化学染色检测DOT1L及其催化产物H3K…查看全部>>
OBJECTIVE To investigate the mechanism of disruptor of telomeric silencing 1-like(DOT1L)on epithelial mesenchymal transition(EMT)in laryngeal squamous cell carcinoma(LSCC)via Notch1 signal pathway.METHODS Fresh tumor tissues and adjacent normal tissues from 30 pathologically confirmed LSCC patients were selected.The positive expression rates of DOT1L and its catalytic product H3K79me3 were detected by immunohistochemistry staining,the relative mRNA expressio…查看全部>>
方勇进;杜欢乐
浙江大学医学院附属金华医院(金华市中心医院)耳鼻咽喉头颈外科,浙江 金华 321000浙江大学医学院附属金华医院(金华市中心医院)耳鼻咽喉头颈外科,浙江 金华 321000
喉肿瘤癌,鳞状细胞细胞增殖细胞凋亡类端粒沉默干扰体1Notch1信号通路上皮间质转化H3K79me3
Laryngeal NeoplasmsCarcinoma,Squamous CellCell ProliferationApoptosisdisruptor of telomeric silencing 1-likenotch1 signaling pathwayepithelial mesenchymal transitionH3K79me3
《中国耳鼻咽喉头颈外科》 2024 (4)
214-218,5
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