国际生殖健康/计划生育杂志2024，Vol.43Issue(3)：207-211,5.DOI:10.12280/gjszjk.20230455
卵巢中-低分化支持-间质细胞瘤一例并文献复习
Modium-Low Differentiation Sertoli-Leydig Cell Tumor of the Ovary:A Case Report and Literature Review
刘书杰 1李明泽 2张海燕3
作者信息
- 1. 250117 济南,山东第一医科大学(山东省医学科学院)
- 2. 滨州医学院
- 3. 临沂市人民医院妇科
- 折叠
摘要
Abstract
The medium-low differentiation Sertoli-Leydig cell tumor(SLCT)has the tendency to become a malignant tumor.A case of SLCT in an 18-year-old young woman was reported.Amenorrhea was the first symptom.Within then 10 months,she gradually developed defeminizing symptoms of breast atrophy,as well as signs of virilization such as protruding Adam's apple,growth of lip beard,deep voice,and clitoral hypertrophy.She had a medical history of thyroid nodule surgery 6 years ago,and the function of thyroid was normal.A large cystic-solid tumor of the left ovary was found under the laparotomic exploration,approximately 10 cm in diameter.Operation was performed,including left adnexectomy,right ovary biopsy,bilateral para-colonic sulcus peritoneal biopsy and greater omentum biopsy.The postoperative pathological diagnosis indicated the medium-low differentiation of SLCT.The patient subsequently recovered well after 4 cycles of chemotherapy with paclitaxel liposome and carboplatin,and was successful childbirth.For women of childbearing age who exhibit de feminization or even masculinization,the possibility of ovarian SLCT should be considered.Fertility preserving surgery and radical surgery should be individualized according to the tumor grading.Patients with high risk of postoperative recurrence should receive timely chemotherapy to reduce the risk of secondary surgery and death.关键词
Sertoli-Leydig细胞瘤/卵巢肿瘤/男性化/抗肿瘤联合化疗方案/保留生育能力Key words
Sertoli-Leydig cell tumor/Ovarian neoplasms/Virilism/Antineoplastic combined chemotherapy protocols/Fertility preservation引用本文复制引用
刘书杰,李明泽,张海燕..卵巢中-低分化支持-间质细胞瘤一例并文献复习[J].国际生殖健康/计划生育杂志,2024,43(3):207-211,5.
