儿科药学杂志2024，Vol.30Issue(5)：33-38,6.DOI:10.13407/j.cnki.jpp.1672-108X.2024.05.009
益生菌预防新生儿坏死性小肠结肠炎效果的Meta分析
Meta-Analysis on Efficacy of Probiotics in the Prevention of Neonatal Necrotizing Nterocolitis
摘要
Abstract
Objective:To systematically review the efficacy and safety of probiotics in the prevention of neonatal necrotizing enterocolitis(NEC).Methods:PubMed,EMBase,the Cochrane Library,Web of Science,CNKI,VIP,Wanfang and CBM were retrieved to collect randomized controlled trials(RCT)of probiotics in the prevention of neonatal NEC.The retrieval time was from the establishment of the databases to Apr.2023.Meta-analysis was performed by using Stata 15.1 SE and RevMan 5.4 software after independent selection of trials,extraction of information and assessment of methodological quality by two evaluators.Results:A total of 29 RCT were enrolled,including 6,354 children.Meta-analysis showed that prophylactic use of probiotics significantly reduced the incidence of neonatal NEC(OR=0.30,95％CI from 0.24 to 0.37,P＜0.05).NEC-related fatality was mentioned in 9 RCT,and prophylactic use of probiotics significantly reduced neonatal NEC-related fatality(OR=0.35,95％CI from 0.17 to 0.70,P＜0.05).Conclusion:Prophylactic use of probiotics can reduce the risk of NEC and related fatality in neonates.关键词
益生菌/新生儿/坏死性小肠结肠炎/Meta分析Key words
probiotics/neonates/necrotizing enterocolitis/Meta-analysis分类
医药卫生引用本文复制引用
杨棋,唐灵玲,李润,贾佳佳,陈雅岚..益生菌预防新生儿坏死性小肠结肠炎效果的Meta分析[J].儿科药学杂志,2024,30(5):33-38,6.基金项目
四川省科技计划项目,编号2021JDRC0161. （）
