中医药治疗膜性肾病大鼠蛋白尿研究进展OA

TCM treatments of membranous nephropathy(MN)rats with proteinuria include tonifying kidney and activating blood circu-lation,banking up and strengthening absorption,tonifying kidney and removing wind,nourishing qi and activating blood circulation to e-liminate dampness,cooling blood to expel turbidity and detoxification,etc.The representative formulas include Spleen-Invigorating and Kidney-Replenishing and Blood-Activating Formula,Shendi Granules,Formula for Reinforcing the Healthy Qi and Eliminating Wind,Astragalus and Os Draconis Formula for Dredging the Kidney,Compound Snake-Dragon Capsules,etc.The active ingredients of Chinese drugs also have the effect of improving proteinuria in MN rats,including alkaloids,polyphenols,terpenes,flavonoids,etc.compound for-mulas of Chinese drugs and active ingredients can play a role in the treatment of MN through anti-inflammatory,anti-oxidative stress,an-ti-apoptosis,reducing the deposition of immune complexes and inhibiting glomerular podocyte mesenchymal transformation.The current research has the following deficiencies:(1)The research of Chinese drugs'active ingredients is mostly in the experimental stage,lacking sufficient clinical evidence;(2)The research of compound formulas of Chinese drugs for the treatment of MN lacks unified syndrome differentiation and efficacy judgment standards;(3)The mechanism of TCM in the treatment of MN proteinuria is still unclear.In the fu-ture,clinical trials should be strengthened to promote the transformation of achievements,and high-quality,multi-center,large-sample clinical research should be carried out to further study its target and signal pathway.