河南中医2024，Vol.44Issue(5)：804-810,7.DOI:10.16367/j.issn.1003-5028.2024.05.0148
中医药治疗膜性肾病大鼠蛋白尿研究进展
Research Progress of TCM in the Treatment of Proteinuria in Rats with Membranous Nephropathy
摘要
Abstract
TCM treatments of membranous nephropathy(MN)rats with proteinuria include tonifying kidney and activating blood circu-lation,banking up and strengthening absorption,tonifying kidney and removing wind,nourishing qi and activating blood circulation to e-liminate dampness,cooling blood to expel turbidity and detoxification,etc.The representative formulas include Spleen-Invigorating and Kidney-Replenishing and Blood-Activating Formula,Shendi Granules,Formula for Reinforcing the Healthy Qi and Eliminating Wind,Astragalus and Os Draconis Formula for Dredging the Kidney,Compound Snake-Dragon Capsules,etc.The active ingredients of Chinese drugs also have the effect of improving proteinuria in MN rats,including alkaloids,polyphenols,terpenes,flavonoids,etc.compound for-mulas of Chinese drugs and active ingredients can play a role in the treatment of MN through anti-inflammatory,anti-oxidative stress,an-ti-apoptosis,reducing the deposition of immune complexes and inhibiting glomerular podocyte mesenchymal transformation.The current research has the following deficiencies:(1)The research of Chinese drugs'active ingredients is mostly in the experimental stage,lacking sufficient clinical evidence;(2)The research of compound formulas of Chinese drugs for the treatment of MN lacks unified syndrome differentiation and efficacy judgment standards;(3)The mechanism of TCM in the treatment of MN proteinuria is still unclear.In the fu-ture,clinical trials should be strengthened to promote the transformation of achievements,and high-quality,multi-center,large-sample clinical research should be carried out to further study its target and signal pathway.关键词
膜性肾病/中药复方/活性成分/蛋白尿Key words
membranous nephropathy(MN)/compound formulas of Chinese drugs/active ingredient/proteinuria分类
医药卫生引用本文复制引用
张寒,赵幸如,吴宇清,高坤..中医药治疗膜性肾病大鼠蛋白尿研究进展[J].河南中医,2024,44(5):804-810,7.基金项目
青年岐黄学者培养项目{国中医药人教发[2020]7号} （）
江苏省中医药领军人才项目{苏中医科教[2023]17号} （）
