基于生物信息学分析和实验验证筛选影响肝癌患者预后的铁死亡调控基因OA北大核心CSTPCD
Screening of ferroptosis-related genes affecting the prognosis of hepatocellular carcinoma patients based on bioinformatics analysis and experimental validation
目的:通过生物信息学技术分析影响肝癌患者生存预后的铁死亡调控基因(ferroptosis-related genes,FRGs),并在细胞和组织层面进行验证.方法:从TCGA数据库下载肝癌基因表达矩阵和临床数据集,并从ferrdb数据库获取与铁死亡相关的基因.使用LASSO回归分析,构建风险比例模型,并通过受试者工作特征曲线(receiver operating characteristic,ROC)回顾患者1、2、3年生存率,使用单因素和多因素…查看全部>>
Objective:To screen ferroptosis-related genes(FRGs)affecting the prognosis of hepatocellular carcinoma patients based on bioinformatics technology.and validate them at cellular and tissue levels.Methods:Gene expression and clinical datasets of hepatocellular carcinoma were downloaded from TCGA database,and iron death-related genes were obtained from ferrdb data-base.LASSO regression analysis was used to construct a risk-proportional model and to compare pati…查看全部>>
姜宇朗;王铮;孙明瑜
上海中医药大学附属曙光医院,上海中医药大学肝病研究所肝肾疾病病证教育部重点实验室,上海 201203||上海中医药大学,上海 201203上海中医药大学附属曙光医院,上海中医药大学肝病研究所肝肾疾病病证教育部重点实验室,上海 201203||上海中医药大学,上海 201203上海中医药大学附属曙光医院,上海中医药大学肝病研究所肝肾疾病病证教育部重点实验室,上海 201203||上海中医药大学,上海 201203
临床医学
肝癌生物信息学铁死亡
BioinformaticsFerroptosisHCC
《海南医学院学报》 2024 (9)
674-682,9
This study was supported by the Fourth Batch of Traditional Chinese Medicine Talent Projects of the State Administration of Traditional Chinese Medicine(2017-124)Shanghai Science and Technology Innovation Action Plan(119401972300)Shandong Province 2021 Key R&D Plan(Major Science and Technology Innovation Project)(2021CXGC010509)Key Discipline of Traditional Chinese Medicine Hepatobiliary Disease,Key Laboratory of Chronic Liver Disease Deficiency and Damage,and Shanghai Key Clinical Laboratory of Traditional Chinese Medicine of the State Administration of Traditional Chinese Medicine(14DZ2273200)(20DZ2272200) 国家中医药管理局第四批中医优才项目(2017-124)上海市科技创新行动计划(19401972300)山东省2021年重点研发计划(重大科技创新工程)(2021CXGC010509)国家中医药管理局中医肝胆病重点学科、慢性肝病虚损重点研究室和上海市中医临床重点实验室资助(14DZ2273200)(20DZ2272200)
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