海南医学院学报2024，Vol.30Issue(9)：691-699,9.DOI:10.13210/j.cnki.jhmu.20230728.003
血肿微创清除联合脑血疏口服液治疗自发性脑出血的疗效及安全性的Meta分析与质量评价
The effect and safety of minimally invasive surgery combined with Naoxueshu oral liquid on spontaneous cerebral hemorrhage:Meta-analysis and quality evaluation
摘要
Abstract
Objective:To systematically evaluate the efficacy and safety of minimally invasive removal of intracranial hemato-ma combined with Naoxueshu treatment for spontaneous cerebral hemorrhage.Methods:Computer search was conducted on Chi-nese and English databases including CNKI,VIP,Wanfang,CBM,PubMed,Embase and the Cochrane Library from the es-tablishment of the database to June 2023,based on inclusion and exclusion criteria to select randomized controlled trials(RCTS)of minimally invasive removal of intracranial hematoma combined with Naoxueshu oral liquid in the treatment of spontaneous in-tracerebral hemorrhage.The risk of bias was evaluated according to the Cochrane Systematic Review Manual,and meta-analysis was performed using Revman5.4 software,and the GRADE system was used to evaluate the evidence quality of outcome indica-tors.Results:Totally 9 RCTs were included,and the total sample size was 739 cases.There were 371 cases in the control group and 368 cases in the experimental group.The results of meta-analysis showed that compared with only conventional West-ern medicine after minimally invasive surgery,combined application of Naoxueshu oral liquid improved the overall clinical effec-tiveness rate[OR=5.47,95%CI=2.28,13.09,P=0.000 1],obviously reduced the score of National Institute of Health Stroke Scale[MD=-3.42,95%CI=-4.97,-1.87,P<0.000 1],and neurological impairment score Chinese stroke patients[MD=-2.30,95%CI=-3.01,-1.58,P<0.000 01],improved Glasgow Coma Scale score[MD=1.51,95%CI=1.13,1.89,P<0.000 01]and Barthel Index(BI)score[MD=6.88,95%CI=4.49,9.27,P<0.000 01],and decreased serum S100 protein[MD=-0.02,95%CI=-0.03,-0.02,P<0.000 01]and AQP4 levels[MD=-0.02,95%CI=-0.03,-0.01,P=0.002].In terms of safety,no serious adverse reactions were reported;gastrointestinal discomfort symptoms includ-ing nausea,abdominal distension and diarrhea were reported in 2 studies;no adverse reactions were reported in the remaining studies.Conclusion:Existing evidence shows that minimally invasive removal of intracranial hematoma combined with Naoxue-shu oral liquid in the treatment of spontaneous cerebral hemorrhage has obvious effects in reducing the degree of neurological im-pairment and consciousness disorder,improving patients'daily living ability,ameliorating patients'quality of life and other as-pects,and has certain safety.关键词
脑出血/脑血疏口服液/微创/血肿清除/Meta分析Key words
Cerebral hemorrhage/Naoxueshu oral liquid/Minimally invasive/Hematoma removal/Meta-analysis分类
医药卫生引用本文复制引用
于苗,张丽娜,丁薇,张根明..血肿微创清除联合脑血疏口服液治疗自发性脑出血的疗效及安全性的Meta分析与质量评价[J].海南医学院学报,2024,30(9):691-699,9.基金项目
This study was supported by Beijing University of Chinese Medicine Dongzhimen Hospital Horizontal Special Project Funding Project(HX-DZM-2018004) 北京中医药大学东直门医院横向专项课题资助项目(HX-DZM-2018004) （HX-DZM-2018004）
