海南医学院学报2024，Vol.30Issue(9)：700-706,7.DOI:10.13210/j.cnki.jhmu.20231011.001
GSDMD介导的肝细胞焦亡在急性肝衰竭中的致病机制
Pathogenesis of GSDMD-mediated pyroptosis of hepatocytes in acute liver failure
摘要
Abstract
Gasdermin D(GSDMD)is a widely expressed protein that can be activated by inflammatory factors within hepato-cytes.Once activated,the N-terminal domain of GSDMD(GSDMD-N)will form pores,leading to rupture of cell membranes and leakage of cytoplasm,ultimately leading to cell death.Pyrozosis is the most characteristic mode of inflammatory lytic cell death mediated by GSDMD.Recent studies have found that activation of GSDMD amplifies the inflammatory response and induc-es pyrosis of liver cells,thereby accelerating the progression of acute liver failure.This article focuses on the pathogenic mecha-nism and potential therapeutic targets of GSDMD-mediated hepatocyte pyrozosis in acute liver failure,in order to provide new ideas for finding potential intervention targets for the effective treatment of acute liver failure.关键词
GSDMD/细胞焦亡/急性肝衰竭/潜在靶点Key words
GSDMD/Cell pyroptosis/Acute liver failure/Potential targets分类
临床医学引用本文复制引用
关海梅,曾阳玲,王恬雯,谢宝华,李国宝,毛德文..GSDMD介导的肝细胞焦亡在急性肝衰竭中的致病机制[J].海南医学院学报,2024,30(9):700-706,7.基金项目
This study was supported by National Natural Science Foundation General Project(82274434),and National Natural Science Foundation of China Regional Fund Project(81960841,82060848) 国家自然科学基金面上项目(82274434) （82274434）
国家自然科学基金地区基金项目(81960841、82060848) （81960841、82060848）
