河南中医2024，Vol.44Issue(5)：744-748,5.DOI:10.16367/j.issn.1003-5028.2024.05.0138
益气解毒方治疗原发性肝癌临床研究
Clinical Study on Qi-Replenishing and Detoxification Decoction in the Treatment of Primary Liver Cancer
摘要
Abstract
Objective:To observe the clinical efficacy of Qi-Replenishing and Detoxification Decoction on primary liver cancer and its in-fluence on the expression of hypoxia inducible factor-1α(HIF-1α)and related cytokines in patients'serum.Methods:A total of 80 pa-tients with primary liver cancer were divided into the control group and the experimental group according to the random number table method,with 40 cases in each group.The control group was given apatinib mesylate for oral treatment,while the experimental group was given Qi-Replenishing and Detoxification Decoction on the basis of the control group.The levels of serum HIF-1α,endothelial growth factor(VEGF),matrix metalloproteinase(MMP)-2,and MMP-9 in the two groups were quantitatively detected by ELISA before treat-ment and after 8 weeks of treatment respectively,and the clinical efficacy and incidence of adverse reactions in the two groups were compared.Results:The remission rate of the experimental group was 37.5%,which was higher than that of the control group:20%,and the difference was statistically significant(P<0.05).After treatment,the levels of MMP-2,MMP-9,VEGF,and HIF-1αin the two groups were lower than those before treatment,while the levels of MMP-2 and HIF-1α in the experimental group were lower than those in the control group,and all the differences were statistically significant(P<0.05).The incidence of hypertension and fatigue in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05),but there was no statistically significant difference in the incidence of rash,hand-foot syndrome,fever,diarrhea,and proteinuria between the two groups(P>0.05).Conclusion:Qi-Replenishing and Detoxification Decoction for the treatment of primary liver cancer can relieve the clinical efficacy of patients,reduce the levels of HIF-1α and MMP-2,and inhibit tumor angiogenesis.关键词
原发性肝癌/益气解毒方/甲磺酸阿帕替尼/中西医结合疗法/缺氧诱导因子-1α/内皮生长因子/基质金属蛋白酶-2/基质金属蛋白酶-9分类
医药卫生引用本文复制引用
任娟,刘海军,沈莉莉,曹振健,翟笑枫,王祥麒,殷晓聆,侯风刚..益气解毒方治疗原发性肝癌临床研究[J].河南中医,2024,44(5):744-748,5.基金项目
上海市中医药管理局——中医非药物疗法示范中心建设子项目[ZY(2021-2023)-0204-05] （2021-2023）
上海市嘉定区卫生和计划生育委员会中医药科研项目(2019-KY-ZYY-06) （2019-KY-ZYY-06）
