激光生物学报2024，Vol.33Issue(2)：97-107,11.DOI:10.3969/j.issn.1007-7146.2024.02.001
液-液相分离:细胞内的调控机制和疾病发展
Liquid-liquid Phase Separation:Intracellular Regulatory Mechanisms and Disease Development
摘要
Abstract
Liquid-liquid phase separation(LLPS)is a biophysical phenomenon within cells that holds significance in cellular regulation,signal transduction,and various biological processes.Over recent years,it has caught considerable attentions.This paper delves into the fundamental concepts,mechanisms of formation,physiological functions,and disease associations related to LLPS.Furthermore,it projects future research trajectories and potential applications.Investigating LLPS offers fresh insights into cellular regulatory mechanisms and disease progression,simultaneously opening avenues for drug development and bio-technological innovations.关键词
液-液相分离/无膜细胞器/调控机制/生理功能/疾病发展Key words
liquid-liquid phase separation/membrane-less organelles/regulatory mechanisms/physiological function/dis-ease development分类
生物科学引用本文复制引用
王丽,王拥军,万兵,张允雷,郭忠良,张秀伟..液-液相分离:细胞内的调控机制和疾病发展[J].激光生物学报,2024,33(2):97-107,11.基金项目
国家自然科学基金项目(81971726) （81971726）
南京市卫生科技发展专项资金项目(YKK22220) （YKK22220）
南京市江宁医院青年基金项目(JNYYZXKY202205,JNYYZXKY202305) （JNYYZXKY202205,JNYYZXKY202305）
南京医科大学康达学院科研发展基金项目(KD2023KYJJ220). （KD2023KYJJ220）
