激光生物学报2024，Vol.33Issue(2)：108-114,7.DOI:10.3969/j.issn.1007-7146.2024.02.002
组蛋白去乙酰化酶HDAC5调控乳腺癌的研究进展
Research Progress on the Regulation of Breast Cancer by Histone Deacetylases HDAC5
摘要
Abstract
Breast cancer ranks as one of the most prevalent malignancies globally,predominantly affecting the female popula-tion.Notably,the expression of class IIa histone deacetylases(HDACs),particularly histone deacetylase 5(HDAC5),exhibits significant variation between breast cancer patients and healthy individuals.This differential expression positions HDAC5 as a promising biomarker for breast cancer and potentially other cancer types.Furthermore,HDAC5 has emerged as a credible mo-lecular target for anticancer therapeutics.This review aims to concisely summarize the structural characteristics of HDAC5,its contributory role in the pathogenesis of breast cancer,and the therapeutic potential of HDAC5 inhibitors.We will discuss the feasibility of detecting HDACs,designing histonedeacetylase inhibitors(HDACi),and identifying effective drug targets in con-junction with HDACi.Our goal is to offer strategic insights for advancing breast cancer treatment,focusing on the application of HDACi in managing breast cancer tumors.关键词
乳腺癌/组蛋白去乙酰化酶/组蛋白去乙酰化酶5/组蛋白去乙酰化酶5抑制剂/药物作用靶点Key words
breast cancer/histone deacetylases/histone deacetylases 5/histone deacetylases 5 inhibitor/drug action targets分类
医药卫生引用本文复制引用
刘承华,梅惠卿,张嘉乐,李华琴,吴文梅..组蛋白去乙酰化酶HDAC5调控乳腺癌的研究进展[J].激光生物学报,2024,33(2):108-114,7.基金项目
国家自然科学基金项目(32302139) （32302139）
广州市基础研究计划基础与应用基础研究项目(2023A04J0862) （2023A04J0862）
广东省大学生创新创业训练项目(202310573039). （202310573039）
