精准医学杂志2024，Vol.39Issue(2)：139-143,5.DOI:10.13362/j.jpmed.202402009
中度脂肪肝对原位自体肝移植模型大鼠心脏功能的影响
Effect of moderate fatty liver on cardiac function in orthotopic autologous liver transplantation model rats
摘要
Abstract
Objective To explore the effect of moderate fatty liver on cardiac function in orthotopic autologous liver transplantation model rats.Methods Sixty SPF-grade healthy male SD rats were randomly divided into three groups(20 rats in each group).Group A was fed ordinary diet for 6 weeks and underwent laparotomy followed by separation of the blood vessels and ligaments around the liver and abdominal closure;group B was fed ordinary diet for 6 weeks and underwent orthotopic autologous liver transplantation;group C was fed high-fat diet for 6 weeks and underwent orthotopic autologous liver transplantation.The body mass,liver wet mass,liver index,and serum levels of aspartate aminotransferase(AST)and alanine aminotransferase(ALT)after 6 weeks of feeding,as well as intraoperative blood pressure,pulse rate,respiratory rate,proportion of arrhythmia oc-curring in the new liver stage,and serum levels of lactate dehydrogenase(LDH),α-hydroxybutyrate dehydrogenase(α-HBDH),creatine kinase(CK),creatine kinase isoenzyme(CK-MB),and high-sensitivity cardiac troponin(hs-cTn)at 0,5,10,and 60 min in the new liver stage were compared.Results The body mass,liver wet mass,liver index,and serum AST and ALT levels,as well as intraoperative systolic blood pressure,diastolic blood pressure,pulse rate,respiratory rate,and proportion of arrhythmia occurring in the new liver stage in group C were significantly higher than those in groups A and B(F=36.40-4 060.54,X2=10.91,P＜0.05),with no significant differences between groups A and B(P＞0.05).The serum levels of LDH,α-HBDH,CK,CK-MB,and hs-cTn at different time points in the new liver stage were significantly higher in group C than in groups A and B(F=14.11-1 057.08,P＜0.05),and were significantly higher in group B than in group A(F=12.59-279.94,P＜0.05).Conclusion Moderate fatty liver may lead to the occurrence of arrhythmia in the new liver stage in liver transplantation,reduce cardiac func-tion,and exacerbate intraoperative stress response.关键词
肝移植/移植,自体/脂肪肝/肝功能试验/心律失常,心性/乳酸脱氢酶类/羟丁酸脱氢酶/肌酸激酶/同工酶类/肌钙蛋白Key words
Liver transplantation/Transplantation,autologous/Fatty liver/Liver function tests/Arrhythmias,car-diac/Lactate dehydrogenases/Hydroxybutyrate dehydrogenase/Creatine kinase/Isoenzymes/Troponin分类
医药卫生引用本文复制引用
王楷文,董河,吕琳,刘欢,蔡金贞..中度脂肪肝对原位自体肝移植模型大鼠心脏功能的影响[J].精准医学杂志,2024,39(2):139-143,5.基金项目
青岛市医药卫生科研计划项目(2021-WJZD198) （2021-WJZD198）
