miR-126对皮肤黑色素瘤C8161迁移、侵袭作用机制的研究OACSTPCD
A Study on the Mechanism of miR-126 on the Migration and Invasion of Cutaneous Melanoma C8161
本研究主要观察微小RNA-126-3p(miR-126)的差异性表达对人皮肤黑色素瘤(CM)细胞株C8161的迁移、侵袭性的影响,并探究了Janus蛋白酪氨酸激酶2/信号传导与转录激活因子3(JAK2/STAT3)通路和上皮-间质转化(EMT)过程在其中的角色.采用细胞转染法实现miR-126的差异性表达,用JAK2/STAT3通路抑制剂AG490、激动剂Coumermycin A1处理miR-126差异表达的细胞,并将C8161细胞分为对照组(…查看全部>>
This study focused on the effects of the differential expression of microRNA-126-3p(miR-126)on migration and invasion of human cutaneous melanoma(CM)cell line C8161,and the role of Janus tyrosine protein kinase 2/signaling and transcriptional activator 3(JAK2/STAT3)pathway and epithelial-mesenchymal transition(EMT)process were investigated.Dysregulation of miR-126 was achieved by cell transfection,and miR-126-deregulated cells were treated with the JAK2/STAT…查看全部>>
禚欣欣;顾丽娟;周晓晗
淮安市第五人民医院皮肤性病美容科,淮安 223300淮安市第五人民医院皮肤性病美容科,淮安 223300淮安市第五人民医院皮肤性病美容科,淮安 223300
临床医学
皮肤黑色素瘤微小RNA-126-3pJanus蛋白酪氨酸激酶2/信号传导与转录激活因子3迁移侵袭
cutaneous melanomamicroRNA-126-3pJanus tyrosine protein kinase 2/signal transduction and transcription activator 3migrationinvasion
《激光生物学报》 2024 (2)
167-175,9
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