军事医学2024，Vol.48Issue(4)：267-272,6.DOI:10.7644/j.issn.1674-9960.2024.04.004
干细胞外泌体对肺型氧中毒的保护作用和机制
Protective effect and mechanism of mesenchymal stem cell derived exosomes against pulmonary oxygen toxicity
摘要
Abstract
Objective To investigate the role and mechanism of exosomes derived from mesenchymal stem cells in hyperbaric oxygen caused pulmonary oxygen toxicity.Methods Mice were divided into the control group that was exposed to normal air,and hyperbaric oxygen exposure groups treated with phosphate buffer saline(PBS)or exosomes,respectively.PBS and exosome treatment were given one day prior to exposure.Mice were subjected to 0.23 MPa pure oxygen for 8 hours.The lung wet-dry ratio,inflammation,exudation and pathological injury were analyzed,while cell death and antioxidant related molecules were detected.Results Pretreatment with exosome significantly attenuated lung injury caused by hyperbaric oxygen exposure by decreasing the lung wet-dry ratio,inflammation,and cell apoptosis.Conclusion Prophylactic administration of exosomes derived from mesenchymal stem cells can alleviate hyperbaric oxygen induced pulmonary oxygen poisoning by attenuating cell death and inflammation.关键词
外泌体/肺型氧中毒/肺损伤Key words
exosome/pulmonary oxygen toxicity/lung injury分类
生物科学引用本文复制引用
徐胜,崔立昆,王舒,陈杰,包晓辰,王越,赵云鹏..干细胞外泌体对肺型氧中毒的保护作用和机制[J].军事医学,2024,48(4):267-272,6.基金项目
国家自然科学基金(82071789) （82071789）
上海市Ⅳ类高峰学科建设基金项目 （）
