兰州大学学报（医学版）2024，Vol.50Issue(3)：28-34,7.DOI:10.13885/j.issn.1000-2812.2024.03.005
颈动脉周围脂肪密度预测颅内斑块易损性的可行性研究
Feasibility of pericarotid fat density in predicting intracranial arterial plaque vulnerability
摘要
Abstract
Objective To investigate the correlation of pericarotid fat density with the different types of carotid plaque and the vulnerability of intracranial plaques.Methods Data of 90 patients who were diagnosed of carotid artery atherosclerotic plaque and had undergone carotid artery computed tomography angiography and high resolution vascular wall magnetic resonance imaging were retrospectively analyzed.Carotid plaques were divided into a calcified plaque group(n=22),mixed plaque group(n=23)and non-calcified plaque group(n=45)according to plaque composition on carotid artery computed tomography angiography.A total of 49 patients with ipsilateral intracranial artery plaque were screened from the mixed plaque group and non-calcified plaque group with more severe inflammation of perivascular adipose tissue,and the intracranial artery plaques were divided into a vulnerable plaque group(n=36)and stable plaque group(n=13)according to high resolution vascular wall magnetic resonance imaging.Pericarotid fat density was identified and measured using a combination of Perivascular Fat Analysis Tool software and manual profiling.Independent sample t test,one-way anova,Mann-Whitney U test,Kruskal-Wallis test and Chi-square test were used to compare the differences between the groups.A receiver operating characteristic curve analysis model was plotted to assess the vulnerability of intracranial plaque.Results The pericarotid fat density of calcified plaque,mixed plaque and non-calcified plaque groups were-53.03[-46.02,-56.12],-43.18[-39.30,-46.07],and-42.88[-39.86,-47.29],respectively.Compared with the calcified plaque group,the pericarotid fat densi-ty in the non-calcified plaque group and mixed plaque group were higher,and the difference was statistically significant(P<0.001).Pericarotid fat density(P=0.003,OR=1.165,95%CI:[1.054,1.287]),as an independent risk factor for vulnerable intracranial plaque,had a good predictive value for the vulnerability of intracranial arterial plaque,with the area under the curve being 0.786,and sensitivity and specificity being 91.67%and 61.54%,respectively.Conclusion Pericarotid fat density is an effective marker for predicting the vulnerability of different types of carotid artery plaque and intracranial artery plaque,and can provide support for imaging diagnosis.关键词
颈动脉周围脂肪密度/高分辨率血管壁磁共振成像/计算机断层成像血管造影/颈动脉斑块/颅内动脉易损斑块Key words
pericarotid fat density/high resolution vascular wall magnetic resonance imaging/computed tomography angiography/carotid plaque/intracranial artery plaque vulnerability分类
医药卫生引用本文复制引用
刘春翠,张艳利,徐静菲,马芹芹,王莎,雷军强..颈动脉周围脂肪密度预测颅内斑块易损性的可行性研究[J].兰州大学学报（医学版）,2024,50(3):28-34,7.基金项目
兰州大学学生创新创业行动计划资助项目(20230060207) （20230060207）
