岭南现代临床外科2024，Vol.24Issue(1)：69-75,7.DOI:10.3969/j.issn.1009-976X.2024.01.011
钇-90微球放射栓塞联合靶向和免疫治疗后成功肝移植:一例报道并文献复习
Successful liver transplant after Yttrium-90 microsphere radioembolization combined with targeted and immunotherapy:a case report and literature review
摘要
Abstract
Objective To discuss successful liver transplantation in advanced hepatocellular carcinoma patients after yttrium-90 microsphere radioembolization(Y90-RE)combination of targeted and immuno-therapy:a clinical case report and literature review.Methods A retrospective analysis of a case of advanced hepatocellular carcinoma patient who underwent successful liver transplantation after Y90-RE combination of targeted and immunotherapy at our center was performed.The relevant treatment methods and postoperative disease changes were analyzed,and the latest domestic and international literature progress was summarized.Results The patient was a 41-year-old middle-aged man.After Y90-RE combination target-immune therapy,he underwent liver transplantation.During the perioperative period,human immunoglobulin pulse therapy was administered,and a combined immunosuppressive scheme of tacrolimus and glucocorticoids was given early after surgery.The patient's liver function gradually improved within 2 weeks after surgery.However,mild elevations of transaminases were detected on the 15th and 68th days after surgery,accompanied by mild acute rejection identified by liver biopsy.Both episodes were resolved by strengthening immunosuppressive treatment.Now,after 6 months of follow-up,the patient's liver function is normal,and no tumor recurrence is observed.Conclusion Y90-RE combined target-immune therapy can provide a treatment option for advanced hepatocellular carcinoma patients.关键词
肝癌/肝移植/钇-90微球放射栓塞治疗/靶免治疗/排斥反应Key words
liver cancer/liver transplantation/Yttrium-90 microsphere radioembolization/targeted immunotherapy/rejection reaction分类
医药卫生引用本文复制引用
陈焕权,何才华,代天星,黄文薮,袁峰,王晓明,罗燕君,汪国营..钇-90微球放射栓塞联合靶向和免疫治疗后成功肝移植:一例报道并文献复习[J].岭南现代临床外科,2024,24(1):69-75,7.基金项目
广东省自然科学基金面上项目(2022A1515010519) （2022A1515010519）
广州市基础研究计划市校(院)联合资助项目(202201020439) （院）
广州市卫健委广州市特色技术(2023C-TS18) （2023C-TS18）
