集成技术2024，Vol.13Issue(3)：39-53,15.DOI:10.12146/j.issn.2095-3135.20231031001
非天然碱基基因密码扩展DNA数据存储的机遇与挑战
The Opportunities and Challenges of Expanding DNA Data Storage with Non-natural Base Gene Code
摘要
Abstract
At present,traditional storage technologies mainly use silicon-based materials as storage media,but the existing silicon resources in the world cannot meet the growing data storage needs of data.With the development of the data era,innovation in storage technology has faced challenges.DNA molecules store rich genetic information,and from the perspective of chemical biology,DNA molecules can be used as a medium for data information storage.This provides a new opportunity for storage technology.Unnatural base nucleotides can expand the genetic alphabet and increase the storage capacity,but there are still many issues to be resolved in their practical applications.This article reviews the progress of DNA storage technology,analysing the current state of DNA storage,unresolved technical challenges,and development prospects.Furthermore,it introduces unnatural base pairs(UBPs)as a new direction in synthetic biology,highlighting their potential advantages and technical challenges in the field of DNA information storage.关键词
DNA分子存储/化学生物学/非天然碱基核苷酸Key words
DNA molecular storage/chemical biology/non-natural base nucleotides分类
生物科学引用本文复制引用
殷晓荷,张舒颖,张瑞峰,尚林春,李凌君..非天然碱基基因密码扩展DNA数据存储的机遇与挑战[J].集成技术,2024,13(3):39-53,15.基金项目
国家自然科学基金项目(22077027,U23A20106) This work is supported by National Natural Science Foundation of China(22077027,U23A20106) （22077027,U23A20106）
