集成技术2024，Vol.13Issue(3)：54-73,20.DOI:10.12146/j.issn.2095-3135.20231030003
基于纳米孔读取的DNA存储发展与展望
Development and Prospects of DNA Storage Based on Nanopore Readout
摘要
Abstract
In the era of data explosion,the global demand for data storage has far exceeded the existing storage capacity.DNA,as a natural carrier of genetic information,provides a stable,efficient,and sustainable data storage solution.The current process of DNA storage is divided into six main parts:encoding,writing,preservation,access,reading,and decoding;and nanopore sequencing technology has been widely used to read information stored in DNA.This review systematically introduces the principle and research history of nanopore-based DNA signal detection,and the applications of nanopore sequencing in DNA storage.Moreover,it summarizes the applications of machine learning in nanopore detection,particularly highlighting the integration of novel nanopore detection techniques with machine learning.This review presents a new direction for the development of nanopore technology and lays the foundation for building a better practical DNA storage system.关键词
纳米孔测序/纳米孔检测/DNA存储/机器学习Key words
nanopore sequencing/nanopore detection/DNA storage/machine learning分类
生物科学引用本文复制引用
林艺生,武瑞君,钱珑,张成..基于纳米孔读取的DNA存储发展与展望[J].集成技术,2024,13(3):54-73,20.基金项目
国家重点研发计划项目(2021YFF1200100) （2021YFF1200100）
国家自然科学基金项目(62073133,62273008,12090054) （62073133,62273008,12090054）
之江实验室(2022RD0AB03) （2022RD0AB03）
预研项目(31511090301) This work is supported by National Key Research and Development Program of China(2021YFF1200100),National Natural Science Foundation of China(62073133,62273008,12090054),Zhejiang Lab(2022RD0AB03),Prestudy Project(31511090301) （31511090301）
