临床误诊误治2024，Vol.37Issue(4)：52-56,5.DOI:10.3969/j.issn.1002-3429.2024.04.011
血清YKL-40与气道炎性因子在婴幼儿喘息中的表达及临床意义
Expression and Significance of Serum YKL-40 and Inflammatory Factors in Infants and Young Children with Wheezing
摘要
Abstract
Objective To investigate the expression and clinical significance of serum YKL-40 and airway inflamma-tory factors interleukin-5(IL-5)and interleukin-8(IL-8)in infants and young children with wheezing.Methods A total of 70 children with acute onset of wheezing(acute stage)admitted from June 2021 to May 2023 were selected,including 32 with the first onset of wheezing,and 38 with repeated wheezing.Of them,34 patients were in the recovery stage after treatment.In addition,22 healthy infants and young children undergoing physical examination during the same period were selected as healthy control group.Children with repeated wheezing were divided into positive group(n =23)and negative group(n =15)according to asthma predictive index(API).Serum YKL-40,IL-5 and IL-8 levels in the above groups were detected,and the correlation of YKL-40 with IL-5,IL-8,peripheral blood neutrophils and eosinophils was analyzed.Results The serum levels of YKL-40,IL-5 and IL-8 in children with asthma in acute stage were higher than those in patients with asthma in convalescent stage and healthy control group(P＜0.01).The serum levels of YKL-40 and IL-8 in the repeated wheezing group were higher than those in the first wheezing group(P＜0.01).There were no significant differences in serum YKL-40,IL-5 and IL-8 lev-els between API positive group and API negative group(P＞0.05).Serum YKL-40 was positively correlated with IL-8(r = 0.926,P＜0.001),but was not correlated with IL-5,absolute value of peripheral blood eosinophils and absolute value of neutrophils(P＞0.05).Conclusion Serum YKL-40,IL-5 and IL-8 may be involved in the process of acute airway inflam-mation in infants and young children with wheezing,and YKL-40 may be associated with neutrophil inflammation.The elevat-ed level of serum YKL-40 may be a risk factor of acute onset and recurrent wheezing,but it is not associated with the API.关键词
喘息/哮喘/YKL-40/白细胞介素-5/白细胞介素-8/嗜酸粒细胞/中性粒细胞/婴幼儿Key words
Wheezing/Asthma/YKL-40/Interleukin-5/Interleukin-8/Eosinophils/Neutrophils/Infants and young children分类
医药卫生引用本文复制引用
王淑玉,郑一博,杨蕾,李矢云,马晓琳,刘凡,张伟..血清YKL-40与气道炎性因子在婴幼儿喘息中的表达及临床意义[J].临床误诊误治,2024,37(4):52-56,5.基金项目
河北省卫生健康委员会重点科技研究计划课题(20211386) （20211386）
