脐灸配合健脾益气通便汤治疗儿童功能性便秘的疗效观察OACSTPCD
Therapeutic observation of umbilical moxibustion plus Jian Pi Yi Qi Tong Bian Tang for functional constipation in children
目的 观察脐灸配合健脾益气通便汤治疗儿童功能性便秘的临床疗效及其对中医症候积分、肠道微生态和血清肠神经递质的影响.方法 将 106 例儿童功能性便秘患者随机分为治疗组 56 例和对照组 50 例.治疗组采用脐灸配合健脾益气通便汤治疗,对照组采用单纯口服健脾益气通便汤治疗.观察两组治疗前后各项主要症状评分、中医症候积分、肠道微生态(双歧杆菌、乳杆菌、大肠埃希菌数量)及血清肠神经递质[一氧化氮(nitric oxide,NO)、P物质(substance P,SP)、生长抑素(somatostatin,SS)]水平的变化情况,比较两组临床疗效及治疗期间不良反应发生率.结果 两组治疗后各项主要症状评分、中医症候积分及血清NO、SS水平均较同组治疗前显著下降,双歧杆菌、乳杆菌、大肠埃希菌数量及血清 SP 水平均显著上升,差异均具有统计学意义(P＜0.05).治疗组治疗后各项主要症状评分、中医症候积分及血清NO、SS水平均明显低于对照组,双歧杆菌、乳杆菌、大肠埃希菌数量及血清SP水平均明显高于对照组,两组比较差异均具有统计学意义(P＜0.05).治疗组治疗后总有效率及治疗期间不良反应发生率分别为 96.4%和 5.4%,对照组分别为 84.0%和 8.0%,两组总有效率比较,差异具有统计学意义(P＜0.05).结论 脐灸配合健脾益气通便汤治疗儿童功能性便秘疗效确切,可改善患者各项临床症状和中医症候,纠正肠道微生态紊乱,调节肠道菌群,纠正肠神经递质水平.
Objective To observe the clinical efficacy of umbilical moxibustion plus Jian Pi Yi Qi Tong Bian Tang in treating functional constipation in children and the effects on the symptom score of traditional Chinese medicine(TCM),intestinal microbiota,and serum intestinal neurotransmitters.Method A total of 106 children with functional constipation were randomized into a treatment group with 56 cases and a control group with 50 cases.The treatment group received umbilical moxibustion plus Jian Pi Yi Qi Tong Bian Tang,and the control group only received oral administration of Jian Pi Yi Qi Tong Bian Tang for treatment.The two groups were observed for changes in each primary symptom score,TCM symptom score,intestinal microbiota(counts of Bifidobacterium,Lactobacillus,and Escherichia coli),and the levels of serum intestinal neurotransmitters[nitric oxide(NO),substance P(SP),and somatostatin(SS)]after the treatment.The clinical efficacy and adverse reaction rate were compared between the two groups.Result After the treatment,each primary symptom score,TCM symptom score,and serum levels of NO and SS dropped in both groups,and the counts of Bifidobacterium,Lactobacillus,and Escherichia coli and the serum SP level increased,all showing statistical significance(P＜0.05).After the intervention,each primary symptom score,TCM symptom score,and serum levels of NO and SS were lower in the treatment group than in the control group,and the counts of Bifidobacterium,Lactobacillus,and Escherichia coli and the serum SP level were higher in the treatment group;the between-group differences were statistically significant(P＜0.05).The total effective rate after the treatment and the adverse reaction rate during the trial were 96.4%and 5.4%,respectively,in the treatment group,versus 84.0%and 8.0%in the control group;the two groups had a significant difference in comparing the total effective rate(P＜0.05).Conclusion Umbilical moxibustion plus Jian Pi Yi Qi Tong Bian Tang is effective in treating children's functional constipation.This method can improve clinical symptoms and TCM symptoms,correct disordered intestinal dysbiosis,regulate bowel flora,and restore intestinal neurotransmitter levels.
陈欢;赵敏;耿文婧
石家庄市人民医院,石家庄 050000
中医学
灸法脐灸药饼灸疗法便秘,功能性儿童肠道微生态肠神经递质健脾益气通便汤
MoxibustionUmbilical moxibustionMedicinal cake-partitioned moxibustionConstipation,FunctionalChildrenIntestinal microbiotaIntestinal neurotransmittersJian Pi Yi Qi Tong Bian Tang
《上海针灸杂志》 2024 (005)
510-515 / 6
河北省全科医学临床科研基金(2020QK029)
评论