上海针灸杂志2024，Vol.43Issue(5)：539-543,5.DOI:10.13460/j.issn.1005-0957.2024.05.0539
温针配合穴位贴敷及药物干预乳腺癌化疗相关性恶心呕吐的临床研究
Clinical study of warming needle combined with acupoint application and drug intervention on breast cancer chemotherapy induced nausea and vomiting
摘要
Abstract
Objective To observe the clinical effect of warming needle combined with acupoint application and drug intervention on breast cancer chemotherapy induced nausea and vomiting(CINV).Method A total of 110 breast cancer patients with postoperative adjuvant chemotherapy were randomly divided into the observation group and the control group,with 55 cases in each group.The control group was treated with intravenous drip of tropisetron hydrochloride for injection 30 minutes before chemotherapy,and the observation group was treated with warm needle combined with acupoint application on the basis of the control group 1 day before chemotherapy.The nausea and vomiting symptom scores and serum 5-hydroxytryptamine(5-HT)levels were observed at different time points before and after chemotherapy,and the incidence of CINV was compared between the two groups.Result The incidence of CINV in the observation group was 34.5%,which was significantly lower than 56.4%in the control group,and the difference was statistically significant(P＜0.05).The symptom scores of nausea and vomiting on the 3rd day after chemotherapy in the two groups were significantly higher than those before chemotherapy,and the symptom scores of nausea and vomiting on the 5th and 7th day after chemotherapy were significantly lower than those on the 3rd day of chemotherapy in the same group,and the differences were statistically significant(P＜0.05).The symptom scores of nausea and vomiting in the observation group on the 3rd,5th and 7th day after chemotherapy were significantly lower than those in the control group,and the differences were statistically significant(P＜0.05).The serum 5-HT levels of the two groups on the 7th day after chemotherapy were significantly higher than those before chemotherapy(P＜0.05).The serum 5-HT level of the observation group was significantly lower than that of the control group on the 7th day after chemotherapy,and the difference was statistically significant(P＜0.05).Conclusion Warming needle combined with acupoint application and drug intervention can reduce the incidence of CINV in breast cancer,help to relieve nausea and vomiting,and its mechanism may be related to the reduction of 5-HT level.关键词
温针疗法/穴位贴敷法/术后恶心呕吐/手术后并发症/乳腺癌/5-羟色胺Key words
Warming needle therapy/Acupoint application/Postoperative nausea and vomiting/Postoperative complications/Breast cancer/5-hydroxytryptamine分类
医药卫生引用本文复制引用
韦柳红,张艳芳,李艳色,杨双利,刘荣,唐金珠..温针配合穴位贴敷及药物干预乳腺癌化疗相关性恶心呕吐的临床研究[J].上海针灸杂志,2024,43(5):539-543,5.基金项目
广西壮族自治区中医药管理局自筹经费科研课题项目(GZZC2020309) （GZZC2020309）
广西壮族自治区卫生健康委员会课题项目(Z20210205) （Z20210205）
