上海针灸杂志2024，Vol.43Issue(5)：549-554,6.DOI:10.13460/j.issn.1005-0957.2024.05.0549
针刺配合翁沥通胶囊治疗良性前列腺增生的疗效观察
Therapeutic observation of acupuncture plus Weng Li Tong capsules for benign prostatic hyperplasia
摘要
Abstract
Objective To observe the clinical efficacy of acupuncture plus Weng Li Tong capsules in treating benign prostatic hyperplasia(BPH)and its effects on serum levels of tumor necrosis factor-α(TNF-α)and prostate specific antigen(PSA).Method A total of 119 patients with BPH were randomly allocated to group A(40 cases),group B(38 cases),and group C(41 cases).Group A was treated with acupuncture,group B was prescribed oral Weng Li Tong capsules,and group C received acupuncture plus oral Weng Li Tong capsules.Before and after the treatment,the three groups were observed for changes in the urodynamic parameters[postvoid residual urine(PVR),maximum urine flow(Qmax),and maximum detrusor pressure],international prostate symptom score(IPSS),quality of life(QOL)score,symptom score of traditional Chinese medicine(difficulty urinating,frequent nocturia,soreness and weakness in the low back and knees,and bloating in the lower abdomen),and laboratory indexes[serum TNF-α,PSA,interleukin-6(IL-6),and epidermal growth factor(EGF)].The clinical efficacy was compared among the three groups.Result After the treatment,the PVR,maximum detrusor pressure,IPSS score,QOL score,laboratory indexes,and traditional Chinese medicine symptom scores decreased,and the Qmax increased in the three groups,all showing statistical significance(P＜0.05).After the intervention,the PVR,maximum detrusor pressure,IPSS score,QOL score,laboratory indexes,and traditional Chinese medicine symptom scores were significantly lower in group C than in groups A and B,and the Qmax was significantly higher in group C compared to the other two groups(P＜0.05).There were no significant differences in the outcome measures between groups A and B after the intervention(P＞0.05).The total effective rate was 92.7%in group C,higher than 70.0%in group A and 73.7%in group B,and the differences were statistically significant(P＜0.05).Conclusion Acupuncture plus Weng Li Tong capsules can effectively treat BPH,down-regulating the TNF-α and PSA levels and improving clinical symptoms.关键词
针刺疗法/前列腺增生/针药并用/肿瘤坏死因子-α/前列腺特异性抗原Key words
Acupuncture therapy/Prostatic hyperplasia/Acupuncture medication combined/Tumor necrosis factor-α/Prostate specific antigen分类
医药卫生引用本文复制引用
刘永存,赵会谢,刘国伟..针刺配合翁沥通胶囊治疗良性前列腺增生的疗效观察[J].上海针灸杂志,2024,43(5):549-554,6.基金项目
河北省中医药管理局科研计划项目(2020345) （2020345）
