实用肝脏病杂志2024，Vol.27Issue(3)：361-365,5.DOI:10.3969/j.issn.1672-5069.2024.03.011
体检人群血浆致动脉粥样硬化指数诊断代谢相关脂肪性肝病效能分析
Diagnostic performance of atherogenic index of plasma in predicting patients with metabolic-associated fatty liver disease from physical examination population
摘要
Abstract
Objective This study was conducted to investigate diagnostic performance of atherogenic index of plasma(AIP)in predicting patients with metabolic-associated fatty liver disease(MAFLD)from physical examination population.Methods 4988 individuals underwent physical examination in the Physical Examination Center,West China Hospital,affiliated to Sichuan University between July 2020 and December 2022.Routine blood fat was detected for calculation of AIP.Multivariate Logistic regression analysis was applied to reveal risk factors,and receiver operating characteristic curve(ROC)was used to assess diagnostic efficacy.Results Of 4988 individuals at physical examination,1589 patients(32.4％)was found having MAFLD;hyperlipidemia was common in patients with MAFLD,and AIP was 0.2(0.0-0.4),much greater than[0.1(0.1-0.3),P＜0.001]in those without MAFLD;multivariate Logistic regression analysis showed that AIP,TG,HDL,LDL and TC were all the independent risk factors for MAFLD existence(P＜0.05);ROC analysis demonstrated the AUC was 0.785 by AIP predicting MAFLD,much higher than TG(0.764),HDL(0.750),LDL(0.568)OR TC(0.552)doing;the AUC was 0.817 by AIP in diagnosing female MAFLD,much higher than 0.714 in diagnosing male MAFLD,and it was 0.825 in predicting MAFLD in persons younger than 45 year old,much higher than 0.742 in predicting MAFLD in those older than 45 year old(P＜0.001).Conclusion AIP has a satisfactory diagnostic performance in predicting MAFLD,which might be used for screening at physical examination centers.关键词
代谢相关脂肪性肝病/血浆致动脉粥样硬化指数/受试者工作特征曲线/诊断Key words
Metabolic-associated fatty liver disease/Atherogenic index of plasma/Receiver operation characteristic curve/Diagnosis引用本文复制引用
曹焱芬,邹昊轩,谢艳..体检人群血浆致动脉粥样硬化指数诊断代谢相关脂肪性肝病效能分析[J].实用肝脏病杂志,2024,27(3):361-365,5.基金项目
四川省卫生健康委员会科研课题(编号:20PJ180) （编号:20PJ180）
