实用肝脏病杂志2024，Vol.27Issue(3)：394-397,4.DOI:10.3969/j.issn.1672-5069.2024.03.019
乙型肝炎肝硬化并发门静脉血栓形成患者中性粒细胞胞外陷阱标志物变化
Changes of serum neutrophil extracellular trap markers in patients with hepatitis B liver cirrhosis complicated by portal vein thrombosis
摘要
Abstract
Objective This study was conducted to investigate the changes of serum neutrophil extracellular trap(NETs)markers in patients with hepatitis B liver cirrhosis(LC)complicated by portal vein thrombosis(PVT).Methods 55 patients with LC caused by hepatitis B viral infection were admitted to our hospital between September 2018 and October 2022,the clinical materials was retrieved from the HIS system and the PVT was diagnosed by ultrasonography(US).Serum myeloperoxidase(MPO),neutrophil elastase(NE)and citrullinated histone H3(CitH3)levels were assayed by ELISA.Results The US check-up revealed PVT in 21 cases(38.2％)in our series;the model for end-stage liver disease score,the percentages of Child class C and splenectomy history in patients with PVT were 18.2(17.6,19.5),52.4％and 42.9％,all significantly greater than[13.2(9.3,16.8),14.7％and 2.9％,P＜0.05]in patients without PVT;serum bilirubin,D-dimer,neutrophil/lymphocyte ratio,MPO,NE and CitH3 levels in patients with PVT were 25.6(21.6,36.0)μmol/L,1095.0(532.5,2202.5)ng/ml,2.3(1.9,4.2),42.4(20.7,78.9)ng/ml,2468.2(1344.8,5620.6)ng/ml and 79.2(44.8,126.2)ng/ml,all significantly greater than[18.9(16.5,28.3)μmol/L,390.0(280.0,680.0)ng/ml,1.9(1.2,2.6),10.8(5.6,16.0)ng/ml,623.5(241.4,1006.3)ng/ml and 28.8(10.4,39.6)ng/ml,respectively,P＜0.05],while serum albumin level was(31.5±5.8)g/L,much lower than[(35.4±5.8)g/L,P＜0.05]in patients without PVT.Conclusion The splenectomy might increase the incidence of PVT in patients with hepatitis B infection-induced LC,and conceal the blood routine manifestations of hypersplenism,while the increased serum NETs markers could remind the necessary of in time clinical management.关键词
肝硬化/脾切除/门静脉血栓形成/中性粒细胞胞外陷阱Key words
Liver cirrhosis/Splenectomy/Portal vein thrombosis/Neutrophil extracellular traps markers引用本文复制引用
吴大海,刘其林,卢杰夫,梁玉梅..乙型肝炎肝硬化并发门静脉血栓形成患者中性粒细胞胞外陷阱标志物变化[J].实用肝脏病杂志,2024,27(3):394-397,4.基金项目
广西壮族自治区南宁市科学与技术开发研究计划项目(编号:ZC20193006) （编号:ZC20193006）
