生殖医学杂志2024，Vol.33Issue(5)：676-681,6.DOI:10.3969/j.issn.1004-3845.2024.05.019
生殖细胞减数分裂端粒挂膜分子机制概述
Summary of mechanisms under telomere-nuclear attachment in meiosis of germ cells
摘要
Abstract
Germ cells produce gametes through meiosis,and the telomere-nuclear envelop(NE)attachment is the prerequisite for this vital physiological process.The proteins interact with each other to ensure the telomere-NE attachment and facilitate proper chromosome pairing,synapsis and homologous recombination during meiosis prophase I.In this paper,we will summarize findings about structures and functions of telomere-NE attachment related proteins and their complex,including Shelterin complex,meiosis specific linker of the nucleoskeleton and cytoskeleton complex(LINC),inner membrane related TERB1-TERB2-MAJIN(TTM)complex,and the SPDYA-CDK2 complex.关键词
减数分裂/染色体/端粒/端粒挂膜/非梗阻性无精子症Key words
Meiosis/Chromosome/Telomere/Telomere-NE attachment/Non-obstructive azoospermia分类
医药卫生引用本文复制引用
马阿妮,刘东腾,张键..生殖细胞减数分裂端粒挂膜分子机制概述[J].生殖医学杂志,2024,33(5):676-681,6.基金项目
深圳市孔雀计划(KQTD20190929172749226) （KQTD20190929172749226）
国家自然科学基金(82301907) （82301907）
深圳市科技计划资助(JCYJ20220818101218040) （JCYJ20220818101218040）
深圳市代谢健康重点实验室(ZDSYS20210427152400001) （ZDSYS20210427152400001）
