天津中医药2024，Vol.41Issue(5)：672-680,9.DOI:10.11656/j.issn.1672-1519.2024.05.21
三七总皂苷生物利用度提升制剂新技术研究进展
Research progress on new technologies to improve bioavailability of Panax notoginseng saponins
逯文敏 1王曦 1王向涛1
作者信息
- 1. 黑龙江中医药大学药学院,哈尔滨 150004||中国医学科学院北京协和医学院药用植物研究所,北京 100193
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摘要
Abstract
Panax notoginseng saponins(PNS)are dammarane-type triterpenoid saponins extracted from the root of panax notoginseng,which have been used as natural medicines for many years because of their diverse pharmacological activities and medicinal values.However,the therapeutic potential of PNS is largely limited by their low bioavailability,mainly due to their high polarity,poor membrane permeability,instability in the gastrointestinal tract,and extensive metabolism in the body.This article reviewed the pharmacological effects,absorption and metabolic characteristics of PNS,the key factors affecting their bioavailability,effective strategies to improve their bioavailability,in order to deepen the understanding of PNS in different areas such as clinical treatment and disease prevention,to design a more efficient drug delivery system and maximize the therapeutic potential of PNS.关键词
三七总皂苷/体内吸收代谢/制剂新技术/生物利用度Key words
Panax notoginseng saponin/absorption and metabolism in the body/new technologies for formulations/bioavailability分类
医药卫生引用本文复制引用
逯文敏,王曦,王向涛..三七总皂苷生物利用度提升制剂新技术研究进展[J].天津中医药,2024,41(5):672-680,9.
