实用肝脏病杂志2024，Vol.27Issue(3)：345-348,4.DOI:10.3969/j.issn.1672-5069.2024.03.007
应用超声评分联合STE/STQ定量检测肝脏硬度评估慢性乙型肝炎患者肝纤维化程度价值研究
Liver fibrosis assessment by US elastography in patients with chronic hepatitis B
摘要
Abstract
Objective The aim of this study was to investigate the diagnostic performance of sound touch elastography(STE)and sound touch quantify(STQ)combined with ultrasound(US)score for assessment of liver fibrosis in patients with chronic hepatitis B(CHB).Methods 106 patients with CHB were enrolled in our hospital between January 2020 and December 2022,and they all underwent liver biopsies for the assessment of liver fibrosis Metavir staging(≥F2 as significant liver fibrosis).The liver stiffness measurement(LSM)was obtained by STE and STQ.The ultrasound score for liver fibrosis was calculated according to the two-dimensional ultrasonography.The receiver operating characteristic(ROC)curve was applied to assess the diagnostic efficacy of US parameters.Results Among the 106 patients with CHB,the ≥F2 liver fibrosis were found in 62 cases and＜F2(no significant liver fibrosis)in 44 cases;the LSMSTE,LSMSTQ and LSMUS in patients with significant liver fibrosis were(12.7±2.2)kPa,(13.3±2.3)kPa and(10.5±2.2),all significantly greater than[(9.2±2.1)kPa,(8.9±1.7)kPa and(7.2± 1.3),respectively,all P＜0.05]in patients without significant liver fibrosis;the ROC analysis showed that the AUCs were 0.869(95％CI:0.803-0.935),0.809(95％CI:0.728-0.891)and 0.767(95％CI:0.679-0.855),when the LSMSTE,LSMSTQ and LSMUS were applied for predicting the significant liver fibrosis,and the diagnostic performance of the three parameter combination was much superior to any one of them(the AUC was 0.949,with the 95％CI of 0.912-0.986,P＜0.05).Conclusion The combination of LSMSTE,LSMSTQ and LSMUS is greatly efficacious in predicting significant liver fibrosis in patients with CHB,and as a non-invasive diagnosis,it is worthy of further clinical verification.关键词
慢性乙型肝炎/肝纤维化/超声/声触诊弹性成像/声触诊弹性测量/诊断Key words
Hepatitis B/Liver fibrosis/Ultrasonography/Sound touch elastography/Sound touch quantify/Diagnosis引用本文复制引用
彭玉静,郭航,陈俊光..应用超声评分联合STE/STQ定量检测肝脏硬度评估慢性乙型肝炎患者肝纤维化程度价值研究[J].实用肝脏病杂志,2024,27(3):345-348,4.基金项目
广东省科技厅科研基金资助项目(编号:2021JH03102) （编号:2021JH03102）
