实用肝脏病杂志2024，Vol.27Issue(3)：357-360,4.DOI:10.3969/j.issn.1672-5069.2024.03.010
非酒精性脂肪性肝病合并T2DM患者血清成纤维细胞生长因子-21和分泌型卷曲相关蛋白5水平变化及其临床意义探讨
Changes of serum fibroblast growth factor-21 and secreted frizzled related protein 5 in patients with non-alcoholic fatty liver disease and T2DM
摘要
Abstract
Objective The aim of this study was to explore the changes and clinical implications of serum fibroblast growth factor-21(FGF21)and secreted frizzled related protein 5(SFRP5)in patients with non-alcoholic fatty liver disease(NAFLD)and diabetes mellitus type 2(T2DM).Methods 101 patients with NAFLD,including nonalcoholic fatter liver(NAFL)in 64 cases,nonalcoholic steatohepatitis(NASH)in 25 cases and liver cirrhosis(LC)in 12 cases,and 81 patients with NAFLD and T2DM,including NAFL in 58 cases,NASH in 16 cases and LC in 7 cases,were enrolled in this study between May 2020 and March 2023,and the fasting blood glucose(FBG)and fasting insulin(FINS)levels were detected,and the homeostasis model assessment of insulin resistance(HOMA-IR)was calculated.Serum FGF21 and SFRP5 levels were detected by ELISA.Results The FBG,serum FINS,the HOMA-IR and serum FGF21 levels in patients with NAFLD and concomitant T2DM were(8.7±1.4)mmol/L,(28.9±5.8)μIU/mL,(11.1±2.7)and(304.8±36.0)pg/mL,all significantly higher than[(5.5±1.2)mmol/L,(20.8±4.1)μJU/mL,(5.1±1.5)and(267.6±34.5)pg/mL,respectively,P＜0.05],while serum SFRP5 level was(6.8± 1.2)pg/mL,much lower than[(10.3±2.2)pg/mL,P＜0.05]in patients with NAFLD;serum total cholesterol,triglyceride,high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels in patients with NAFLD and T2DM were(6.7± 1.0)mmol/L,(3.7±0.6)mmol/L,(1.3±0.2)mmol/L and(3.4±0.8)mmol/L,all not significantly different as compared to[(6.2±0.9)mmol/L,(4.1±0.5)mmol/L,(1.3±0.3)mmol/L and(3.2±0.7)mmol/L,respectively]in patients with NAFLD(P＞0.05);serum SFRP5 levels in patients with T2DM and underlying NAFL,NASH and LC were(7.8±1.1)pg/mL,(6.4±0.8)μg/mL and(5.1±0.7)μg/mL,all significantly lower than[(11.9±2.1)pg/mL,(9.8±1.6)μg/mL and(8.4±1.1)pg/mL,respectively,P＜0.05],while serum FGF21 levels were(295.6±31.2)pg/mL,(316.8±32.9)pg/mL and(353.6± 36.7)pg/mL,all significantly higher than[(255.1±32.5)pg/mL,(279.5±33.4)pg/mL and(309.7±35.8)pg/mL,respectively,P＜0.05]in patients with NAFL,with NASH or with LC.Conclusion Serum FGF21 level significantly increases,while serum SFRP5 level significantly decreases in patients with NAFLD and concomitant T2DM,which might be applied to predict the severity of the entity in clinical practice.关键词
非酒精性脂肪性肝病/2型糖尿病/成纤维细胞生长因子-21/分泌型卷曲相关蛋白5Key words
Non-alcoholic fatty liver diseases/Type 2 diabetes mellitus/Fibroblast growth factor-21/Secreted frizzled related protein 5引用本文复制引用
孙世磊,刘翠翠,李曙光,鲁科翔..非酒精性脂肪性肝病合并T2DM患者血清成纤维细胞生长因子-21和分泌型卷曲相关蛋白5水平变化及其临床意义探讨[J].实用肝脏病杂志,2024,27(3):357-360,4.基金项目
山东省自然科学基金面上项目(编号:ZR2021MH148) （编号:ZR2021MH148）
