上海针灸杂志2024，Vol.43Issue(5)：487-493,7.DOI:10.13460/j.issn.1005-0957.2023.13.0021
头针配合低频重复经颅磁刺激治疗痉挛性脑性瘫痪疗效观察
Scalp acupuncture combined with low frequency repetitive transcranial magnetic stimulation in the treatment of spastic cerebral palsy
摘要
Abstract
Objective To observe the clinical efficacy of scalp acupuncture combined with low frequency repetitive transcranial magnetic stimulation in the treatment of spastic cerebral palsy based on electroencephalogram spectrum technology.Method Ninety spastic cerebral palsy patients and 20 healthy children were divided into the case group and normal group.The density of spectrum(δ、θ、α、β、γ)of resting state electroencephalogram(EEG)signals were collected and compared.Then the case group was randomly divided into group A,group B and group C,with 30 cases in each group.On the basis of routine rehabilitation training,group A was treated with scalp acupuncture,group B was treated with low frequency repetitive transcranial magnetic stimulation,and group C was treated with scalp acupuncture combined with low frequency repetitive transcranial magnetic stimulation.The gross motor function measure-88(GMFM-88)score(D,E regions),diagnosis of Gesell developmental diagnosis scale score,the indicators of intracranial vertebral artery blood flow state in basal ganglia[(left vertebral artery(LVA),right vertebral(RLA),basilar artery(BA)average flow velocity],inflammatory factors[serum interleukin-6(IL-6),interleukin-33(IL-33),tumor necrosis factor α(TNF-α)]and the changes of spectral density of EEG signals were observed before and after treatment in the three groups.The clinical efficacy of the three groups was compared.Result In group C,GMFM-88 scores and Gesell developmental diagnostic scale scores in D and E regions after treatment were significantly higher than those before treatment,the average flow velocity of LVA,RLA and BA was significantly faster,and the levels of inflammatory factors were significantly lower than those before treatment,and the differences were statistically significant(P＜0.05).After treatment,the GMFM-88 scores and each score of the Gesell developmental diagnosis Scale in D and E regions in group C were significantly higher than those in group A and group B(P＜0.05).The average flow velocities of LVA,RLA,and BA in group C were significantly faster than those in group A and group B,and the levels of each inflammatory factor in group C were significantly lower than those in group A and group B(P＜0.05).Before treatment,the δ and θ spectrum densities of EEG signals in the case group were significantly higher than those in the normal group(P＜0.05).After treatment,the δ and θ spectral densities of EEG signals in the three groups were significantly lower than those before treatment(P＜0.05).The total effective rate of group C was 83.3%,which was significantly higher than that of group A(63.3%)and group B(56.7%),the differences were statistically significant(P＜0.05).Conclusion On the basis of routine rehabilitation training,scalp acupuncture combined with low frequency repetitive transcranial magnetic stimulation is effective in the treatment of spastic cerebral palsy,which can improve the motor function and cognitive function of patients.The mechanism is mainly related to the down-regulation of inflammatory factors and the regulation of blood flow state of intracranial vertebrobasilar artery.关键词
针刺疗法/头针/脑性瘫痪/重复经颅磁刺激/脑电信号频谱/炎症因子Key words
Acupuncture therapy/Scalp acupuncture/Cerebral palsy/Repetitive transcranial magnetic stimulation/The spectrum of EEG signals/Inflammatory factors分类
医药卫生引用本文复制引用
阳芸,李水帝,罗丽辉,黄振波,常燕群,徐宁,吴满红..头针配合低频重复经颅磁刺激治疗痉挛性脑性瘫痪疗效观察[J].上海针灸杂志,2024,43(5):487-493,7.基金项目
广东省中医药局科研项目(20221046) （20221046）
