疑难病杂志2024，Vol.23Issue(5)：590-594,5.DOI:10.3969/j.issn.1671-6450.2024.05.016
FZD7、GAL-8在肝内胆管癌中的表达及其与临床病理特征和预后的关系
The expression of FZD7 and GAL-8 in intrahepatic cholangiocarcinoma and their relationship with clinical pathologi-cal features and prognosis
摘要
Abstract
Objective To analyze the expression of Frizzled homolog protein 7(FZD7)and galactin 8(GAL-8)in in-trahepatic cholangiocarcinoma(ICC),and their relationship with clinical pathological features and prognosis.Methods Eighty-four ICC patients who visited Department of Oncology Yulin First Hospital from April2017 to April2020 were select-ed.Immunohistochemical methods were used to detect the expression of FZD7 and GAL-8 proteins in tissues.The relation-ship between FZD7 and GAL-8 were conducted by Spearman correlation analysis.Kaplan-Meier method was used to ana-lyze the differences in survival prognosis among ICC patients with different FZD7 and GAL-8 expressions.The prognostic factors for ICC were analyzed by Coxregression analysis.Results The positive rates of FZD7 and GAL-8 in ICC cancer tissue were 73.81%(62/84)and 71.43%(60/84),respectively,which were higher than those in adjacent cancer tissue by 4.76%(4/84)and 7.14%(6/84)(χ2=83.950,72.770,all P<0.001).FZD7 was positively correlated with GAL-8 expression in ICC(rs=0.745,P<0.001).The positive rates of FZD7 and GAL-8 were higher in ICCcancer tissues with low differentiation degree,lymph node metastasis and TNM stage Ⅲ(FZD7:χ2/P=8.221/<0.001,6.097/0.014,13.014/<0.001;GAL-8:χ2/P= 7.207/0.007,5.555/0.018,11.760/0.001).The 3-year overall survival rate of the FZD7 positive group was 32.26%(20/62),which was lower than the negative group's 68.19%(15/22)(Log rank χ2=8.723,P=0.003).The 3-year overall survival rate of the GAL-8 positive group was 28.33%(17/60),which was lower than the GAL-8 negative group's 75.30%(18/24)(Log rank χ2=24.310,P<0.001).TNM stageⅢ,low differentiation degree,lymph node metastasis,FZD7 positivity,and GAL-8 positivity were independent risk factors affecting the prognosis of ICC patients[HR(95%CI)=1.614(1.215-2.145),1.516(1.219-1.884),1.916(1.315-2.791),1.826(1.222-2.729),1.737(1.237-2.438)].Conclusion FZD7 and GAL-8 are upregulated in ICC,both of which are involved in the progression of ICC tumors and serve as tumor markers for evaluating the prognosis of ICC patients.关键词
肝内胆管癌/卷曲同源蛋白7/半乳糖凝集素8/预后Key words
Intrahepatic cholangiocarcinoma/Frizzled homolog protein 7/Galactin 8/Prognosis分类
医药卫生引用本文复制引用
马彦娥,贺双,刘东梅,苏虎艳,王倩如,郝光军..FZD7、GAL-8在肝内胆管癌中的表达及其与临床病理特征和预后的关系[J].疑难病杂志,2024,23(5):590-594,5.基金项目
陕西省科技计划项目(2019M042) Shaanxi Provincial Science and Technology Plan Project(2019M042) （2019M042）
