疑难病杂志2024，Vol.23Issue(5)：599-604,6.DOI:10.3969/j.issn.1671-6450.2024.05.018
高强度聚焦超声消融联合屈螺酮炔雌醇片治疗子宫腺肌病患者的临床疗效及对血管生成因子和子宫动脉血流动力学的影响
Efficacy of high-intensity focused ultrasound ablation combined with drospirenone ethinylestradiol tablets in treating adenomyosis patients and its impacts on angiogenic factors and uterine artery hemodynamics
摘要
Abstract
Objective To investigate the efficacy of high-intensity focused ultrasound(HIFU)ablation combined with drospirenone ethinylestradiol tablets in treating adenomyosis(AD)patients and its impacts on angiogenic factors and uterine artery hemodynamics.Methods A total of 104 AD patients diagnosed and treated in the Obstetrics and Gynecolo-gy Department of the Fifth People's Hospital of Chengdu from February 2021 to February 2023 were selected as the study objects.They were divided into single group(n=52)and combined group(n=52)by random number table method.The single group was treated with HIFU ablation,while the combination group was treated with drospirenone ethinylestradiol tablets on the basis of the single group.Clinical efficacy,angiogenic factors[serum angiopoietin-2(Ang-2),vascular endo-thelial growth factor(VEGF),adiponectin(ADPN)],uterine artery hemodynamics[peak blood flow velocity(PSV),end dias-tolic blood flow velocity(EDV),pulsatile index(PI),resistance index(RI)],ovarian related indicators[estrogen(E2),follicle stimulating hormone(FSH),anti-Mullerian hormone(AMH),luteinizing hormone(LH)]levels,uterine volume,lesion volume and diameter,clinical symptoms(menstrual cycle changes,menstrual prolongation,menstrual blood clotting,increased men-strual flow,daytime urinary frequency,fatigue,pelvic pain,nighttime urinary frequency)scores,and adverse reactions were compared.Results The total effective rate of single group was obviously lower than that of combination group(90.38%vs.75.00%,χ2/P=4.300/0.038).After treatment,the Ang-2,VEGF,E2,AMH,FSH,LH,PSV,EDV,RI,uterine volume,lesion volume,lesion diameter level,and clinical symptom score of the two groups were obviously lower than before treatment,and the combination group were obviously lower than the single group(t/P=3.340/0.001,5.125/<0.001,4.427/<0.001,9.381/<0.001,2.313/0.023,9.795/<0.001,3.149/0.002,3.584/0.001,2.139/0.035,4.151/<0.001,15.493/<0.001,8.814/<0.001,6.605/<0.001,4.583/<0.001,9.112/<0.001,7.522/<0.001,5.427/<0.001,3.425/0.001,4.084/<0.001,8.209/<0.001).After treatment,the ADPN and PI of the 2 groups were higher than those before treatment,and the combined group was significantly higher than the single group(t/P=2.659/0.002,2.801/0.006).There was no significant difference in the total incidence of adverse re-actions between 2 groups(P>0.05).Conclusion The clinicalsymptoms of AD patients are obviously improved after HIFU ablation combined with drospirenone ethinylestradiol treatment,and their levels of angiogenic factors and hemodynamics are obviously reduced,indicating high safety.关键词
子宫腺肌病/高强度聚焦超声消融/屈螺酮炔雌醇/血流动力学/血管生成因子Key words
Adenomyosis/High intensity focused ultrasound ablation/Drospirenone ethinyl estradiol/Hemody-namics/Angiogenic factor分类
医药卫生引用本文复制引用
李莉,刘春桃,刘杨,刘明盛,李丽..高强度聚焦超声消融联合屈螺酮炔雌醇片治疗子宫腺肌病患者的临床疗效及对血管生成因子和子宫动脉血流动力学的影响[J].疑难病杂志,2024,23(5):599-604,6.基金项目
2022 年四川省第一批省级科技计划项目(2022JDRC0141) The first Batch of Provincial-level Science and Technology Plan Projects in 2022(2022JDRC0141) （2022JDRC0141）
