川陈皮素调节RIP1/RIP3/MLKL信号通路对慢性心力衰竭大鼠心肌坏死性凋亡的影响OACSTPCD
The effect of Nobiletin regulating the RIP1/RIP3/MLKL signaling pathway on myocardial necrotic apoptosis in rats with chronic heart failure
目的 探究川陈皮素(Nob)调节受体相互作用蛋白激酶1/受体相互作用蛋白激酶3/混合谱系激酶样结构域蛋白(RIP1/RIP3/MLKL)信号通路对慢性心力衰竭(CHF)大鼠心肌坏死性凋亡的影响及作用机制.方法 于2022 年9 月—2023 年3 月在南方医科大学中心实验室进行实验.建立大鼠CHF模型,将造模成功的75 只大鼠按随机数字表法分为模型组(CHF组)、川陈皮素低剂量组(Nob-L组,7.5 mg·kg-1·d-1 Nob)、川陈皮素中…查看全部>>
Objective To investigate the effect and mechanismof Nobiletin(Nob)on necrotic apoptosis in chronic heart failure(CHF)rats by regulating the receptor interacting protein kinase 1/receptor interacting protein kinase 3/mixed line-age kinase like domain protein(RIP1/RIP3/MLKL)signaling pathway.Methods From September 2022 to March 2023,exper-iment was conducted in Central Laboratory of Southern Medical University.A CHF rat model was established,and 75 suc-cessfully modeled rats were randomly divided into model group(CHF group),low-dose Nob group(Nob-L group,7.5 mg·kg-1·d-1 Nob),mediumdose Nob group(Nob-M group,15 mg·kg-1·d-1 Nob),high-dose Nob group(Nob-H group,30 mg·kg-1·d-1 Nob),and pathway inhibitor Nec-1 group(Nec-1 group,2.45 mg·kg-1·…查看全部>>
张鹏;林桂雄;卓裕丰;程宏基;陈钦修;谢文杰;冯燕玲
511400 广州市番禺区何贤纪念医院心内科511400 广州市番禺区何贤纪念医院心内科511400 广州市番禺区何贤纪念医院心内科511400 广州市番禺区何贤纪念医院心内科511400 广州市番禺区何贤纪念医院心内科511400 广州市番禺区何贤纪念医院心内科511400 广州市番禺区何贤纪念医院心内科
临床医学
慢性心力衰竭川陈皮素RIP1/RIP3/MLKL信号通路炎性反应氧化应激坏死性凋亡大鼠
Chronic heart failureNobiletinRIP1/RIP3/MLKL signaling pathwayInflammatory responseOxidative stressNecrotic apoptosisRat
《疑难病杂志》 2024 (5)
605-612,8
广东省基础与应用基础研究基金项目(2021B1551140064)广州市科技计划项目(202102080548) Guangdong Basic and Applied Basic Research Fund Project(2021B1551140064)Guangzhou Science and Technology Plan Project(202102080548)
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