肠道特征性微生物菌群在结直肠癌诊治中的研究现状OA
Research Status of Intestinal Characteristic Microbial Flora in the Diagnosis and Treatment of Colorectal Cancer
结直肠癌(CRC)是世界上高发病率、高死亡率的恶性肿瘤之一,迫切需要寻找特征性的诊断标志物并进行早期干预、治疗.已有研究表明肠道微生物菌群与CRC的发生发展密切相关,通过对肠道菌群的宏基因组或16SrRNA的测序分析,鉴定出CRC相关的肠道特征性菌群,其丰度、组成的变化有望作为潜在的CRC诊断标志物.本文就结直肠癌的肠道菌群变化特征、检测方法及其作为生物标志物在CRC诊断、进展分期、治疗及预后中的作用进行综述,以期为CRC的临床诊治提供新思路.
Colorectal cancer(CRC)is one of the malignant tumors with high morbidity and mortality in the world.It is urgent to find characteristic diagnostic markers and carry out early intervention and treatment.Previous studies have shown that intestinal microflora is closely related to the occurrence and development of CRC.Through the sequencing analysis of the metagenome or 16S rRNA of intestinal microflora,CRC-related intestinal characteristic microflora is identified,and its abundance and composition changes are expected to be used as potential CRC diagnostic markers.This article reviews the characteristics of intestinal flora changes in colorectal cancer,detection methods and their role as biomarkers in the diagnosis,progression,staging,treatment and prognosis of CRC,in order to provide new ideas for the clinical diagnosis and treatment of CRC.
陈竹芳;杜冀晖
广东医科大学第一临床医学院,广东 东莞 523808||华中科技大学协和深圳医院临床医学转化中心,广东 深圳 518052华中科技大学协和深圳医院临床医学转化中心,广东 深圳 518052
临床医学
肠道菌群结直肠癌生物标志物
Intestinal floraColorectal cancerBiomarkers
《医学信息》 2024 (009)
168-172 / 5
2022年深圳市南山区科技计划重点项目(编号:NS2022001)
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