中国医疗设备2024，Vol.39Issue(5)：26-30,5.DOI:10.3969/j.issn.1674-1633.2024.05.005
18F-FDG-(OAc)4的合成及其在小鼠体内的生物分布
Synthesis of 18F-FDG-(OAc)4 and Its Bio-Distribution in Mice
摘要
Abstract
Objective To analyze the stability and practicality of the positron emission tomography drug synthesizer for the synthesis of 18F-FDG-(OAc)4.Methods Based on the synthesizer and its synthetic process,the synthesis yield and quality control of 18F-FDG-(OAc)4 were carried out,and the similarities and differences in biological distribution in mice between 18F-FDG-(OAc)4 and 18F-FDG were analyzed.Results The success rate of 18F-FDG-(OAc)4 in 3 consecutive batches was 100%,and the yields were 59.64%,60.61%,and 59.72%,respectively.The product solution was colorless and transparent,with radioactive chemical purity was≥96%(Rf value was 0.8-0.9)and radioactive nuclear purity was 100%.There were no significant differences in the radioactive uptake of various organs after injecting 18F-FDG-(OAc)4 and 18F-FDG into mice(P>0.05).Conclusion The synthesizer provides a simple and convenient process for the synthesis of 18F-FDG-(OAc)4 with high synthesis success rate and yield,showing strong stability and practicality.关键词
18F-FDG-(OAc)4/18F-FDG/显像剂制备/生物分布Key words
18F-FDG-(OAc)4/18F-FDG/synthesis of imaging agents/bio-distribution分类
医药卫生引用本文复制引用
何正中,庞丁华,李宁,张实来,杨洪,蒙小飞,杨志,肖国有..18F-FDG-(OAc)4的合成及其在小鼠体内的生物分布[J].中国医疗设备,2024,39(5):26-30,5.基金项目
广西科技计划项目重点研发计划(桂科AB19110015) （桂科AB19110015）
广西生物靶向诊治研究重点实验室开放基金课题(GXSWBX202203 （）
GXSWBX202204 （）
GXSWBX202205) （）
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20190559 （）
Z-A20220680 （）
Z-A20220678) （）
广西高校中青年教师科研基础能力提升项目(2023KY0084) （2023KY0084）
广西医科大学青年科学基金项目(GXMUYSF202226 （）
GXMUYSF202356). （）
