18F-FDG-(OAc)4的合成及其在小鼠体内的生物分布OACSTPCD
Synthesis of 18F-FDG-(OAc)4 and Its Bio-Distribution in Mice
目的 分析正电子药物合成器合成基氟-18标记的四乙酰脱氧葡糖[1,3,4,6-四乙酰基-O-2-18F-2-脱氧-β-D葡萄糖,简称18F-FDG-(OAc)4]的稳定性和实用性.方法 基于合成器及其合成工艺流程,进行18F-FDG-(OAc)4合成产量和质量控制及其与氟-18标记的脱氧葡萄糖(2-[18F]-氟-2-脱氧-D-葡萄糖,简称18F-FDG)在小鼠体内的生物分布异同分析.结果 连续3批合成18F-FDG-(OAc)4的成功率为100%,产率分别为59.64%、60.61%、59.72%,产品溶液为无色透明溶液,放射性化学纯度≥96%(Rf值为0.8～0.9),放射性核纯度为100%.18F-FDG-(OAc)4与18F-FDG注入小鼠,后各个脏器的放射性摄取均无差别,差异无统计学意义(P>0.05).结论 正电子药物合成器合成18F-FDG-(OAc)4的流程简单、便捷,合成成功率和合成产率较高,具有较强的稳定性和实用性.
Objective To analyze the stability and practicality of the positron emission tomography drug synthesizer for the synthesis of 18F-FDG-(OAc)4.Methods Based on the synthesizer and its synthetic process,the synthesis yield and quality control of 18F-FDG-(OAc)4 were carried out,and the similarities and differences in biological distribution in mice between 18F-FDG-(OAc)4 and 18F-FDG were analyzed.Results The success rate of 18F-FDG-(OAc)4 in 3 consecutive batches was 100%,and the yields were 59.64%,60.61%,and 59.72%,respectively.The product solution was colorless and transparent,with radioactive chemical purity was≥96%(Rf value was 0.8-0.9)and radioactive nuclear purity was 100%.There were no significant differences in the radioactive uptake of various organs after injecting 18F-FDG-(OAc)4 and 18F-FDG into mice(P>0.05).Conclusion The synthesizer provides a simple and convenient process for the synthesis of 18F-FDG-(OAc)4 with high synthesis success rate and yield,showing strong stability and practicality.
何正中;庞丁华;李宁;张实来;杨洪;蒙小飞;杨志;肖国有
广西医科大学附属肿瘤医院 核医学科(广西临床重点建设专科),广西 南宁 530021
基础医学
18F-FDG-(OAc)418F-FDG显像剂制备生物分布
18F-FDG-(OAc)418F-FDGsynthesis of imaging agentsbio-distribution
《中国医疗设备》 2024 (005)
26-30 / 5
广西科技计划项目重点研发计划(桂科AB19110015);广西生物靶向诊治研究重点实验室开放基金课题(GXSWBX202203;GXSWBX202204;GXSWBX202205);广西壮族自治区卫生健康委员会自筹经费科研课题(Z20190559;Z-A20220680;Z-A20220678);广西高校中青年教师科研基础能力提升项目(2023KY0084);广西医科大学青年科学基金项目(GXMUYSF202226;GXMUYSF202356).
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