培土抑木针法调节CRF/CRFR1通路修复腹泻型肠易激综合征大鼠肠黏膜屏障的机制研究OA北大核心CSTPCDMEDLINE
Mechanisms of Peitu Yimu acupuncture in repairing intestinal mucosal barrier by regulating CRF/CRFR1 pathway in diarrhea-predominant irritable bowel syndrome rats
目的:基于促肾上腺皮质激素释放因子(CRF)/CRF受体1(CRFR1)通路探讨培土抑木针法对腹泻型肠易激综合征(IBS-D)大鼠肠黏膜屏障功能的影响及机制.方法:将40只雌性SD大鼠随机分为空白组、模型组、电针组、激动剂组,每组10只.除空白组外,其余各组大鼠采用番泻叶浸液灌胃联合慢性不可预知性温和刺激构建IBS-D大鼠模型.针刺组大鼠于造模后针刺一侧"天枢",电针"足三里""太冲"(2 Hz/15 Hz),每次 20 min,隔日左右交替,干…查看全部>>
Objective To investigate the effect of Peitu Yimu(strengthening spleen and soothing liver)acupuncture on intestinal mucosal barrier function and corticotropin-releasing factor(CRF)/CRF receptor 1(CRFR1)pathway in rats with diarrhea-predominant irritable bowel syndrome(IBS-D),so as to explore its underlying mechanism in alleviating IBS-D.Methods Forty female SD rats were randomly divided into blank,model,electroacupuncture(EA),and agonist groups,with 10 rats …查看全部>>
王楷;侯雨君;王路;廖晨希;宋玮;陈颖;周思远
成都中医药大学针灸推拿学院,成都 610075成都中医药大学针灸推拿学院,成都 610075成都中医药大学针灸推拿学院,成都 610075成都中医药大学针灸推拿学院,成都 610075成都中医药大学基础医学院,成都 610075成都中医药大学针灸推拿学院,成都 610075成都中医药大学针灸推拿学院,成都 610075
腹泻型肠易激综合征培土抑木针法电针肠黏膜屏障促肾上腺皮质激素释放因子紧密连接蛋白
Diarrhea-predominant irritable bowel syndromePeitu Yimu(soothing the liver and strengthening the spleen)acupunctureElectroacupunctureIntestinal mucosal barrierCorticotropin-releasing factorTight junction protein
《针刺研究》 2024 (5)
472-479,8
国家自然科学基金项目(No.82074558)
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