针刺研究2024，Vol.49Issue(5)：506-511,6.DOI:10.13702/j.1000-0607.20230220
孙氏头针腹针联合盐酸多奈哌齐治疗阿尔茨海默病的临床观察
Clinical observation on treatment of Alzheimer's disease with Sun's scalp-abdominal acupuncture combined with donepezil hydrochloride
摘要
Abstract
Objective To observe the effect of scalp-abdominal acupuncture combined with donepezil hydrochloride on cognition and life ability of patients with Alzheimer's disease(AD),so as to evaluate its clinical efficacy.Methods Sixty AD patients were collected and randomly divided into control group(30 cases)and observation group(30 cases).Patients in the control group were treated with oral donepezil hydrochloride(5 mg,once daily).Patients in the observation group were treated with scalp-abdominal acupuncture at Baihui(GV20),Yintang(GV24+),Sishencong(EX-HN1),"emotional area",Shenting(GV24),"abdominal area 1""abdominal area 8",and bilateral Fengchi(GB20),Taixi(KI3),Xuanzhong(GB39),Zusanli(ST36)on the basis of control group,and electroacupuncture(10 Hz/50 Hz,0.5 to 5.0 mA)was applied to EX-HN1,"emotional area""abdominal area 1"and"abdominal area 8",once daily,30 min each time.Four weeks as a course of treatment,both the two groups were treated for two consecutive courses.Before and after treatment,the mini-mental state examination(MMSE),AD assessmennt scale-cognitive subscale(ADAS-Cog)and activity of daily living scale(ADL)were evaluated.The clinical efficacy index was calculated and safety was evaluated.Results After treatment,the MMSE and ADL scores were higher(P<0.05)and the ADAS-Cog score was lower(P<0.05)than those before treatment in both groups.Compared with the control group,the MMSE and ADL scores were increased(P<0.05)and ADAS-Cog score was decreased(P<0.05)in the observation group.The total effective rate of the observation group(26/30,86.67%)was higher(P<0.05)than that of the control group(23/30,76.67%).No adverse reactions occurred in both groups during the treatment.Conclusion Scalp-abdominal acupuncture combined with donepezil hydrochloride can effectively improve the cognitive ability and daily living ability of AD patients,and the efficacy is better than that of oral donepezil hydrochloride alone.关键词
阿尔茨海默病/头针/腹针/电针Key words
Alzheimer's disease/Scalp acupuncture/Abdominal acupuncture/Electroacupuncture引用本文复制引用
张思琪,马帅,杨添淞,张淼..孙氏头针腹针联合盐酸多奈哌齐治疗阿尔茨海默病的临床观察[J].针刺研究,2024,49(5):506-511,6.基金项目
国家自然科学基金项目(No.82174509) （No.82174509）
黑龙江省博士后科研启动金项目(No.LBH-Q18123) （No.LBH-Q18123）
黑龙江中医药大学校级优秀创新人才支持计划项目(No.051824) （No.051824）
