针刺研究2024，Vol.49Issue(5)：519-525,7.DOI:10.13702/j.1000-0607.20230278
针刺调控ERK信号通路治疗抑郁症的研究进展
Research progress of acupuncture regulating ERK signaling pathway in the treatment of depression
摘要
Abstract
Acupuncture treatment for depression has definite therapeutic efficacy,and its mechanism has been extensively studied.The extracellular regulatory protein kinase(ERK)signaling pathway is involved in the development and progression of depression.This article reviewed and summarized the research progress on the regulation of the ERK signaling pathway by acupuncture in the treatment of depression in recent years,focusing on the physiological activation and regulatory mechanism of the ERK signaling pathway,its association with the occurrence of depression,and the mechanisms through which acupuncture activates the ERK signaling pathway to treat depression(including enhancing neuronal synaptic plasticity,promoting the release of neurotrophic factors,and inhibiting neuronal apoptosis).Future research could explore the relationship between the ERK pathway and other pathways,investigate other brain regions besides the prefrontal cortex and hippocampus,examine differences in regulatory mechanisms between male and female patients,assess the effects of different acupuncture techniques on the ERK pathway,and increase efforts to explore mechanism of synaptic plasticity regulation,so as to provide reference for the clinical application and mechanism sludy of acupuncture in depression treatment.关键词
针刺/抑郁症/ERK信号通路/分子机制Key words
Acupuncture/Depression/ERK signaling pathway/Molecular mechanism引用本文复制引用
肖敏,李芃菲,马雪娇,严兴科,马重兵..针刺调控ERK信号通路治疗抑郁症的研究进展[J].针刺研究,2024,49(5):519-525,7.基金项目
2023年甘肃省高校青年博士支持项目(No.2023QB-088) （No.2023QB-088）
国家自然科学基金项目(No.82360974) （No.82360974）
甘肃省皇甫谧针灸医院孵化项目(No.ZJKF2204) （No.ZJKF2204）
甘肃中医药大学2020-2021年引进人才科研启动基金项目(No.2023YJRC-01) （No.2023YJRC-01）
甘肃中医药大学科学研究与创新基金项目(No.2021KCYB-1) （No.2021KCYB-1）
