针刺研究2024，Vol.49Issue(5)：526-533,8.DOI:10.13702/j.1000-0607.20230129
针灸治疗腰椎间盘突出症作用机制研究进展
Progress of researches on mechanisms of acupuncture therapy in the treatment of lumbar disc herniation
摘要
Abstract
Lumbar intervertebral disc herniation(LDH)is a common and frequently-occurring disease,which usually causes lumbar and leg pain.Studies have shown that acupuncture can improve the symptoms of LDH patients.In the present paper,we summarize the progress of researches on the mechanisms of acupuncture underlying improvement of symptoms of LDH in recent 10 years from 1)delaying the intervertibral disc degeneration(by down-regulating the expressions of matrix metalloproteinase[MMP]-3 and MMP-4,up-regulating the expressions of diosaccharides and polyglycoprotein,inhibiting apoptosis and promoting mitochondrial autophagy of nucleus pulposus cells,etc.),2)maintaining spinal column stability(by relieving rachiasmus and improving lumbar flexor and extensor muscle strength,lowering the degree of polyfidus edema and fat infiltration,and restoring the biomechanics of the spine),3)regulating inflammation(by inhibiting the production of proinflammatory factors and increasing the production of anti-inflammatory factors,etc.),4)regulating immune response(by promoting the activity of T cells and other immune cells,lowering serum levels of MMP-3,transforming growth factor-β1 and prostaglandin E2,raising serum levels of IgA,IgG and IgM to improve immune function),5)modulating neural structure and function(by promoting myelin regeneration of sciatic nerve fibers,and reducing the edema of Schwann cells'cytoplasm and mitochondria,and improving neural ultrastructure,and sensory and motor functions of peripheral nerves,etc.),6)relieving lumbar pain(by down-regulating expression of Ca2+/calmodulin-dependent protein kinase and activation of lumbar spinal cord glial cells,blocking nociceptive signal conduction,regulating the levels of pain-related factors,etc.),and 7)improving local microcirculation.These results may provide scientific evidence for acupuncture treatment of LDH.关键词
针灸/腰椎间盘突出症/椎间盘退变/作用机制/综述Key words
Acupuncture/Lumbar disc herniation/Intervertebral disc degeneration/Mechanism/Review引用本文复制引用
邸学士,孙文婷,白鹏,陈江,王新茹,梁俊杰,张重阳,潘婷,孟言,张佳佳,冯智伟..针灸治疗腰椎间盘突出症作用机制研究进展[J].针刺研究,2024,49(5):526-533,8.基金项目
2022年青年岐黄学者培养项目(No.国中医药人教函[2022]256号) （No.国中医药人教函[2022]256号）
