医学信息2024，Vol.37Issue(9)：16-22,7.DOI:10.3969/j.issn.1006-1959.2024.09.003
乌头汤治疗腰椎间盘突出症作用机制的网络药理学研究
Network Pharmacology Study on the Mechanism of Wutou Decoction in the Treatment of Lumbar Disc Herniation
摘要
Abstract
Objective To explore the mechanism of Wutou decoction in the treatment of lumbar disc herniation(LDH)by using network pharmacology and molecular docking technology.Methods TCMSP was used to screen out the effective active ingredients and target information of Wutou decoction,and convert them into corresponding gene names;the targets of LDH were obtained from the GeneCard and OMIM databases,and the common targets of the two were obtained by Venny plot.Cytscape was used to construct a"Chinese medicine-active ingredient-disease target"and PPI network diagram,and R software was used to perform GO and KEGG enrichment analysis.Finally,molecular docking of effective active ingredients and key targets was performed.Results A total of 151 effective active components and 52 common targets of Wutou decoction in the treatment of LDH were obtained.The results of the network diagram showed that the core active components included quercetin,kaempferol,luteolin,etc.,and the key targets included IL6,TNF,AKT1,IL1 B,VEGFA,MMP9,etc.The KEGG pathway mainly involved AGE-RAGE,IL-17,TNF and other signaling pathways.The results of molecular docking showed that the binding between the effective active components and the key targets was good.Conclusion Wutou decoction treats LDH through multi-component,multi-target and multi-pathway,which can provide basis and ideas for the follow-up clinical application and research of Wutou decoction.关键词
乌头汤/腰椎间盘突出症/网络药理学/分子对接Key words
Wutou decoction/Lumbar disc herniation/Network pharmacology/Molecular docking分类
医药卫生引用本文复制引用
王淑江,龙胜利..乌头汤治疗腰椎间盘突出症作用机制的网络药理学研究[J].医学信息,2024,37(9):16-22,7.基金项目
贵州省中医药管理局中医药、民族医药科学技术研究课题(编号:QZYY-2023-149) （编号:QZYY-2023-149）
