中国兽医杂志2024，Vol.60Issue(5)：107-112,6.DOI:10.20157/j.cnki.zgsyzz.2024.05.014
重金属诱导的铁死亡与神经毒性关系的研究进展
Research Progress on the Relationship between Heavy Metal Induced Ferroptosis and Neurotoxicity
摘要
Abstract
Heavy metal elements can enter the body of animals through feed and accumulate,affecting the safety of animal-derived food and posing risks to human health.Some common heavy metal ions can induce iron-dependent cell death known as ferroptosis.Ferroptosis is a novel form of iron-dependent cell death characterized by the accumulation of iron and reactive oxygen species within cells,ultimately leading to cell death.Modulating cellular ferroptosis to treat or prevent related neurological damage or diseases has become a hot topic in modern medical research,but its functional changes and specific molecular mechanisms still need further exploration.This article mainly reviews the triggering mechanisms of ferroptosis and the relationship between neurotoxicity induced by common heavy metals in feed and ferroptosis,aiming to provide new directions for the treatment and prevention of such neurological injuries in the future.关键词
铁死亡/重金属/神经毒性/谷胱甘肽过氧化酶4(GPX4)/系统xc-/谷胱甘肽Key words
ferroptosis/heavy metal/neurotoxicity/glutathione peroxidase 4(GPX4)/system xc-/glutathione分类
农业科技引用本文复制引用
沈垚,张宇航,曹凯,陈淳,李存,李道稳..重金属诱导的铁死亡与神经毒性关系的研究进展[J].中国兽医杂志,2024,60(5):107-112,6.基金项目
国家自然科学基金(32302926) （32302926）
中国博士后科学基金(2021M700708) （2021M700708）
农业农村部智慧养殖重点实验室(部省共建)开放基金(2023-TJAUKLSBF-2107) （部省共建）
