中国兽医科学2024，Vol.54Issue(5)：674-679,6.DOI:10.16656/j.issn.1673-4696.2024.0078
猪繁殖与呼吸综合征病毒RNA依赖的RNA聚合酶功能研究进展
Progress in research on the function of porcine reproductive and respiratory syndrome virus RNA-dependent RNA polymerase
摘要
Abstract
Porcine reproductive and respiratory syndrome(PRRS)is an important porcine infectious disease caused by the porcine reproductive and respiratory syndrome virus(PRRSV).Its main clinical features are reproductive disorders in sows and respiratory diseases in growing and finishing pigs,causing huge losses to the global pig industry.Nsp9 is a non-structural protein of PRRSV that plays an important role in the replication and virulence of PRRSV due to its RNA-dependent RNA polymerase(RdRp)function.The Nsp9 is important for the development of future vaccines,because its sequence is highly conserved and contains a T cell epitope.Nsp9 becomes the center of interaction between virus and host proteins during PRRSV infection,especially in genomic RNA replication and transcription.Herein,we summarize the progress of Nsp9 in research on the genetic variation,viral virulence,interactions with other viral proteins and host proteins affecting viral replication,host immune response regulation,the development of antiviral drugs and vaccines,which will provide novel ideas and strategies for the prevention and control of PRRSV.关键词
猪繁殖与呼吸综合征病毒(PRRSV)/RNA依赖的RNA聚合酶(RdRp)/病毒复制/病毒毒力/疫苗研发Key words
porcine reproductive and respiratory syndrome virus(PRRSV)/RNA-dependent RNA poly-merase(RdRp)/virus replication/viral virulence/vaccine development分类
农业科技引用本文复制引用
段宏勇,唐超智,王树茂,王安冉,姜一峰,周艳君,高飞,李丽薇..猪繁殖与呼吸综合征病毒RNA依赖的RNA聚合酶功能研究进展[J].中国兽医科学,2024,54(5):674-679,6.基金项目
国家重点研发计划项目(2022YFD1800305,2022YFD1800804) （2022YFD1800305,2022YFD1800804）
上海市科技兴农项目(2022-02-08-00-12-F01162) （2022-02-08-00-12-F01162）
中国农业科学院科技创新工程项目(CAAS-CSLPDCP-202301) （CAAS-CSLPDCP-202301）
