中国畜牧兽医2024，Vol.51Issue(5)：2228-2236,9.DOI:10.16431/j.cnki.1671-7236.2024.05.043
三萜类化合物对肠道炎症的药理作用
Pharmacological Effects of Triterpenoids on Intestinal Inflammation
摘要
Abstract
Triterpenoids are a class of natural compounds of multiple isoprene units.They have various biological activities such as anti-inflammatory,antioxidant properties and potential therapeutic effects in relieving intestinal inflammation.Firstly,triterpenoids exert their anti-inflammatory effects by suppressing the secretion of inflammatory mediators(interleukins,prostaglandins,tumor necrosis factor)and their related signaling pathways,thereby reducing the production of intestinal inflammation.Secondly,triterpenoids improve the generation of reactive oxygen species,balance the redox system,and reduce oxidative stress damage,leading to their anti-inflammatory properties.Moreover,triterpenoids regulate the NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome and multiple signaling pathways(NF-κB/MAPK/Nrf2 signaling pathways)to improve the levels of immunoglobulins and complement,so achieving immune balance.Fourthly,triterpenoids promote the expression of tight junction proteins,repair damaged intestinal mucosal epithelium,enhance intestinal barrier function,and reduce the penetration of irritants,thus inhibiting intestinal inflammation.Furthermore,triterpenoids exhibit a close relationship with the gut microbiota.They can maintain gut microbiota stability,preserve the integrity of the intestinal epithelial barrier,and reduce the occurrence of intestinal inflammation.In conclusion,triterpenoids protect against intestinal inflammation by regulating inflammation,oxidative stress,immune balance,mucosal barrier and gut microbiota.Although there are certain limitations and challenges in the current research on triterpenoids,this review provides an important reference for further exploration,development and utilization of triterpenoids,and offer new ideas for their application in the field of intestinal inflammation.关键词
三萜类化合物/肠道炎症/氧化应激/免疫平衡/肠道黏膜屏障Key words
triterpenoids/intestinal inflammation/oxidative stress/immune balance/intestinal mucosal barrier分类
农业科技引用本文复制引用
刘李林,谭宇,杨帆,易金娥..三萜类化合物对肠道炎症的药理作用[J].中国畜牧兽医,2024,51(5):2228-2236,9.基金项目
国家自然科学基金(32273084) （32273084）
湖南农业大学大学生创新创业项目(XCX2023105) （XCX2023105）
