中国药物经济学2024，Vol.19Issue(4)：34-42,9.DOI:10.12010/j.issn.1673-5846.2024.04.006
基于网络药理学的民族药古山龙防治糖尿病的作用机制
Therapeutic Effect of Ethnic Medicine Gushanlong on Diabetes based on Network Pharmacology
摘要
Abstract
Objective This study aims to analyze the pharmacological mechanisms of Gushanlong in the treatment of diabetes using methods such as network pharmacology and molecular docking.Methods Target compounds of Gushanlong were screened,and SwissTargetPrediction was employed to predict and filter potential protein targets.A"compound-target"interaction network was constructed,incorporating relevant genes associated with diabetes retrieved from the Disgenet database to form a"compound-target-disease"network.Molecular docking was performed between exclusive components of Gushanlong and crucial proteins.Results Fifteen target compounds of Gushanlong were selected,predicting 146 protein targets.Eighty-four targets were identified as relevant to diabetes,involving 169 pathways such as PI3K-Akt,AMPK,Signaling by Interleukins,etc.Molecular docking analysis demonstrated that exclusive components of Gushanlong exhibited favorable binding capabilities with key targets in the network topology.Conclusion Gushanlong potentially exerts its effects on diabetes and its complications through antioxidant mechanisms,modulation of the apoptosis pathway,reduction of damage to pancreatic islet B cells,promotion of glycolysis,and other pathways.关键词
民族药/古山龙/糖尿病/网络药理学Key words
Ethnic Medicine/Gushanlong/Diabetes/Network Pharmacology分类
医药卫生引用本文复制引用
赵丹,张淼,史志龙..基于网络药理学的民族药古山龙防治糖尿病的作用机制[J].中国药物经济学,2024,19(4):34-42,9.基金项目
云南省兴滇英才支持计划青年人才专项(XDYC-QNRC-2022-0762) （XDYC-QNRC-2022-0762）
云南省科技厅地区高校联合项目青年项目(202101BA070001-244) （202101BA070001-244）
