长期使用质子泵抑制剂所致不良反应及机制OA
Characteristics and Mechanism of Adverse Drug Reactions Caused by Long-term Use of Proton Pump Inhibitors
质子泵抑制剂(PPIs)通过作用于胃壁细胞上的 H+-K+-ATP 酶,抑制胃酸分泌,广泛用于治疗胃酸相关疾病等.长期使用PPIs所致药品不良反应(ADR)可累及多器官系统,相关临床表现为消化系统疾病(胃黏膜病变、肠道微生态紊乱)、泌尿系统疾病(急性间质性肾炎、急性肾损伤)、代谢与营养类疾病(低镁血症、维生素B12 缺乏、高尿酸血症)、肌肉骨骼疾病(骨质疏松与骨折)、内分泌系统疾病(糖尿病)、心血管疾病、神经系统疾病(痴呆)等,大部分ADR发生机制复杂多样.临床用药过程中应充分了解ADR发生特点和机制,警惕PPIs所致ADR,保证其用药安全合理.
OProton pump inhibitors(PPls)inhibit gastric acid secretion by acting on gasric H+-K+-ATP enzymes,which are used as the first choice for the treatment and prevention of digestive acid related diseases.Chronic PPIs use can lead to potentially harmful effects in digestive,urinary,nutrition,skeletal,endocrinium,blood,nervous and other systems,such as abnormal proliferation of gastrointestinal mucosa,intestinal flora disorders,acute kidney injury,acute interstitial nephritis,vitamin Bl2 deficiency,hyperyricemia,hypomagnesemia,osteoporosis,fracture,diabetes,drug-induced thrombocytopenia,anemia,dementia and so on.Most of mechanism were complex.In the course of clinical drug use,we should fully understand the characteristics and mechanism of ADR,be alert to ADR caused by PPIs,and ensure the safety and rationality of drug use.
王丽;于文雯;柳克浩;李敏;郭瑞惠;戚迎梅
济南市药品不良反应和医疗器械不良事件监测中心,济南 250013
药学
质子泵抑制剂H+-K+-ATP酶药品不良反应发生机制合理用药
Proton pump inhibitorH+-K+-ATP aseAdverse drug reactionsMechanism of ADRRational drug use
《中国药物经济学》 2024 (004)
100-103,108 / 5
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