摘要
Abstract
Objective:To analyze the effect of target-controlled infusion of Propofol under the guidance of bispectral index(BIS)monitoring technology on patients undergoing radical resection of colorectal cancer.Method:A total of 100 patients with colorectal cancer admitted to Beijing Fengtai Hospital from January 2022 to December 2023 were selected and divided into two groups according to random number table method,with 50 patients in each group.All patients underwent radical resection of colorectal cancer.The control group received conventional target-controlled infusion of Propofol,while the observation group received target-controlled infusion of Propofol under the guidance of BIS monitoring technology.The surgical indexes,hemodynamic indexes and stress response indexes were compared between the two groups.Result:The dosage of Propofol in the observation group was lower than that in the control group,the incidence of complications was lower than that in the control group,and the induction time,recovery time,extubation time and surgical time were shorter than those in the control group,the differences were statistically significant(P<0.05).At the time of intubation(T1),1 min after intubation(T2),at the time of pneumoperitoneum establishment(T3),and at the end of operation(T4),the heart rate(HR)and mean arterial pressure(MAP)of the two groups were higher than those pre-induction anesthesia(T0),but the MAP and HR of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).At 12 h after surgery,the levels of cortisol(Cor)and norepinephrine(NE)in two groups were lower than those before surgery,and the level of epinephrine(E)was higher than that before surgery,and the levels of Cor and NE in observation group were lower than those in control group,and the level of E was higher than that in control group,the differences were statistically significant(P<0.05).Conclusion:Target-controlled infusion of Propofol under the guidance of BIS monitoring technology can effectively reduce the stress response of patients undergoing radical resection of colorectal cancer,maintain stable hemodynamics,improve the safety of anesthesia and reduce the risk of postoperative complications.关键词
结直肠癌根治术/麻醉深度监测技术/靶控输注方式/丙泊酚Key words
Radical resection of colorectal cancer/Monitoring technique of anesthesia depth/Target-controlled infusion mode/Propofol
