恩格列净在2型糖尿病合并高血压患者中的应用效果及对血管内皮损伤的影响OA
Application Effects of Empagliflozin in Patients with Type 2 Diabetes Mellitus Complicated with Hypertension and Its Influence on Vascular Endothelial Injury
目的:探究恩格列净在2型糖尿病合并高血压患者中的应用效果及对血管内皮损伤的影响.方法:选取2020年1月—2023年7月荆州市第三人民医院收治的100例2型糖尿病合并高血压患者.根据随机数表法将其分为对照组及观察组,各 50 例.对照组给予常规糖尿病与高血压治疗,观察组在对照组基础上给予恩格列净片.比较两组高血压控制效果,不良反应,治疗前、治疗 12 周后血糖指标、血压指标、血管内皮损伤标志物.结果:观察组高血压治疗总有效率显著高于对照组,差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).治疗 12 周后,观察组糖化血红蛋白(HbA1c)、空腹血糖(FPG)及餐后2 h血糖(2 h PG)均显著低于对照组,差异有统计学意义(P<0.05).治疗12周后,观察组 24 h收缩压(24 h SBP)及 24 h舒张压(24 h DBP)、24 h收缩压变异系数(24 h SBP CV)、24 h舒张压变异系数(24 h DBP CV)均显著低于对照组,差异有统计学意义(P<0.05).治疗 12 周后,观察组循环内皮细胞(CEC)、内皮素-1(ET-1)及P选择素(PS)均显著低于对照组,差异有统计学意义(P<0.05).结论:恩格列净在 2 型糖尿病合并高血压患者中的应用效果较好,可有效控制及稳定血压及血糖,并可有效控制血管内皮损伤,因此在 2 型糖尿病合并高血压患者中的应用价值较高.
Objective:To investigate the application effects of Empagliflozin in patients with type 2 diabetes mellitus complicated with hypertension and its influence on vascular endothelial injury.Method:A total of 100 patients with type 2 diabetes complicated with hypertension treated in Jingzhou Third People's Hospital from January 2020 to July 2023 were selected.They were divided into control group and observation group according to random number table method,with 50 cases in each group.The control group was given routine treatment for diabetes and hypertension,and the observation group was given Empagliflozin Tablets on the basis of the control group.The hypertension control effect,adverse reactions,blood glucose index,blood pressure index and vascular endothelial injury marker before treatment and after 12 weeks of treatment were compared between the two groups.Result:The total effective rate of hypertension treatment in observation group was significantly higher than that in control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 12 weeks of treatment,the glycosylated hemoglobin(HbA1c),fasting plasma glucose(FPG)and 2 h postprandial blood glucose(2 h PG)in observation group were significantly lower than those in control group,the differences were statistically significant(P<0.05).After 12 weeks of treatment,24 h systolic blood pressure(24 h SBP)and 24 h diastolic blood pressure(24 h DBP),24-hour systolic blood pressure coefficient of variation(24 h SBP CV)and 24-hour diastolic blood pressure coefficient of variation(24 h DBP CV)in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).After 12 weeks of treatment,circulating endothelial cells(CEC),endothelin-1(ET-1)and P-selectin(PS)in observation group were significantly lower than those in control group,the differences were statistically significant(P<0.05).Conclusion:The application effect of Empagliflozin in patients with type 2 diabetes mellitus combined with hypertension is good,which can effectively control and stabilize blood pressure and blood glucose,and effectively control vascular endothelial damage,so it is of high application value in patients with type 2 diabetes mellitus complicated with hypertension.
杨娟;钟晶晶;周艳
荆州市第三人民医院 湖北 荆州 434000
恩格列净2型糖尿病高血压应用效果血管内皮损伤
EmpagliflozinType 2 diabetesHypertensionApplication effectVascular endothelial injury
《中外医学研究》 2024 (011)
50-53 / 4
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