中国现代医生2024，Vol.62Issue(13)：29-31,3.DOI:10.3969/j.issn.1673-9701.2024.13.008
GGT、ALP和外周血NLR联合检测在肝癌诊断中的应用价值
Application value of combined detection of GGT,ALP and peripheral blood NLR in the diagnosis of liver cancer
宁一珊 1李泰阶 1詹丹 1黄丽秀 1蒋诚传1
作者信息
- 1. 广西医科大学附属武鸣医院医学检验科,广西南宁 530199
- 折叠
摘要
Abstract
Objective To investigate the application value of γ-glutamyltransferase(GGT),alkaline phosphatase(ALP)and peripheral blood neutrophil to lymphocyte ratio(NLR)in liver cancer.Methods 100 patients with liver cancer admitted to Wuming Hospital Affiliated to Guangxi Medical University from January 2012 to December 2020 were retrospectively selected to be included in liver cancer group,100 patients with cirrhosis to be included in cirrhosis group,100 patients with hepatitis to be included in hepatitis group,and 100 healthy physical examination subjects from our hospital during the same period were included in physical examination group.The GGT,ALP and NLR levels of the four groups were compared.Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficacy of each index for liver cancer.Results The levels of NLR,GGT and ALP in liver cancer group were significantly higher than those in cirrhosis group,hepatitis group and physical examination group(P<0.05).The NLR in cirrhosis group was significantly higher than that in physical examination group and hepatitis group(P<0.05).GGT and ALP in cirrhosis group and hepatitis group were significantly higher than those in physical examination group(P<0.05).Spearman correlation analysis showed that NLR was positively correlated with GGT and ALP,and GGT was positively correlated with ALP(P<0.05).When NLR,GGT and ALP were detected separately,area under the curve(AUC)of NLR was the largest(0.943,95％CI:0.901-0.971,P<0.001),and AUC of ALP was the smallest.The AUC of three combined detections was 0.987(95％CI:0.959-0.998),and the sensitivity was 99.0％.Conclusion The combined detection of NLR,GGT and ALP can significantly improve the detection rate of liver cancer,and the combined detection has better application value.关键词
肝癌/γ-谷氨酰转移酶/碱性磷酸酶/中性粒细胞与淋巴细胞比值/诊断价值Key words
Liver cancer/γ-Glutamyltransferase/Alkaline phosphatase/Neutrophil to lymphocyte ratio/Diagnostic value分类
医药卫生引用本文复制引用
宁一珊,李泰阶,詹丹,黄丽秀,蒋诚传..GGT、ALP和外周血NLR联合检测在肝癌诊断中的应用价值[J].中国现代医生,2024,62(13):29-31,3.
