中国现代医生2024，Vol.62Issue(13)：36-39,78,5.DOI:10.3969/j.issn.1673-9701.2024.13.010
IL-1β和IL-18对重症肺炎的诊断意义
The diagnostic significance of IL-1β and IL-18 in severe pneumonia
张素婷 1许银银1
作者信息
- 1. 重庆医科大学附属永川医院检验科,重庆 402160
- 折叠
摘要
Abstract
Objective To explore the diagnostic value of serum interleukin(IL)-1β and IL-18 levels in the severity of pneumonia.Methods A total of 200 patients with pneumonia treated in the Affiliated Yongchuan Hospital of Chongqing Medical University from January to December 2022 were retrospectively selected and divided into mild group(n=100)and severe group(n=100)according to the severity of pneumonia,and 100 healthy people who underwent physical examination in our hospital were included as normal group.The general clinical data,hematology index,fever peak,cough,rales and complications were analyzed.Propensity score matching was performed for patients in mild group and severe group,and the receiver operating characteristic(ROC)curve was used to calculate the diagnostic efficacy of IL-1β and IL-18 before and after matching.Results There were statistically significant differences in IL-1β and IL-18 levels among the three groups(P<0.05),and severe group>mild group>normal group.The cut-off values of IL-1β and IL-18 in the diagnosis of severe pneumonia before matching were 12.169pg/ml and 194.535pg/ml,respectively.IL-1β was more effective than IL-18 in the diagnosis of severe pneumonia(0.490 vs.0.380).The cut-off values of IL-1β and IL-18 in the diagnosis of severe pneumonia after matching were 10.542pg/ml and 191.372pg/ml,respectively.IL-1β was more effective than IL-18 in the diagnosis of severe pneumonia(0.493 vs.0.360).Conclusion IL-1β and IL-18 increase with the severity of pneumonia and have high diagnostic value for severe pneumonia.关键词
肺炎/白细胞介素-1β/白细胞介素-18/诊断效能Key words
Pneumonia/Interleukin-1β/Interleukin-18/Diagnostic efficacy分类
医药卫生引用本文复制引用
张素婷,许银银..IL-1β和IL-18对重症肺炎的诊断意义[J].中国现代医生,2024,62(13):36-39,78,5.
